Euphorbia diterpenoids: isolation, structure, bioactivity, biosynthesis, and synthesis (2013–2021)

Z Zhan, S Li, W Chu, S Yin - Natural Product Reports, 2022 - pubs.rsc.org
Covering: 2013 to 2021 As the characteristic metabolites of Euphorbia plants, Euphorbia
diterpenoids have always been a hot topic in related science communities due to their …

Targeting drug chemo-resistance in cancer using natural products

WH Talib, AR Alsayed, M Barakat, MI Abu-Taha… - Biomedicines, 2021 - mdpi.com
Cancer is one of the leading causes of death globally. The development of drug resistance
is the main contributor to cancer-related mortality. Cancer cells exploit multiple mechanisms …

Jatrophane and rearranged jatrophane-type diterpenes: Biogenesis, structure, isolation, biological activity and SARs (1984–2019)

M Fattahian, M Ghanadian, Z Ali, IA Khan - Phytochemistry reviews, 2020 - Springer
Diterpene compounds specially macrocyclic ones comprising jatrophane, lathyrane,
terracinolide, ingenane, pepluane, paraliane, and segetane skeletons occurring in plants of …

Current and promising antivirals against chikungunya virus

FIL Hucke, JJ Bugert - Frontiers in Public Health, 2020 - frontiersin.org
Chikungunya virus (CHIKV) is the causative agent of chikungunya fever (CHIKF) and is
categorized as a (n)(re) emerging arbovirus. CHIKV has repeatedly been responsible for …

Myrsinane-type diterpenes: A comprehensive review on structural diversity, chemistry and biological activities

E Mendes, C Ramalhete, N Duarte - International Journal of Molecular …, 2023 - mdpi.com
Euphorbia species are important sources of polycyclic and macrocyclic diterpenes, which
have been the focus of natural-product-based drug research due to their relevant biological …

Antitumor Effect of the Ethanolic Extract from Seeds of Euphorbia lathyris in Colorectal Cancer

C Mesas, R Martínez, R Ortíz, M Galisteo… - Nutrients, 2021 - mdpi.com
The seeds of Euphorbia lathyris have been used in traditional medicine to treat various
medical conditions. However, neither all of their active biocompounds nor the molecular …

Dietary diterpenoids

Y Asakawa, H Kenmoku - Handbook of dietary phytochemicals, 2021 - Springer
A number of foods, vegetables, fruits, and beverages (tea, coffee, and liqueur) contain many
kinds of diterpenoids (mainly abietanes, cembranes, clerodanes, cyatanes, dolabellanes …

Jatrophane Diterpenoids from Euphorbia peplus as Multidrug Resistance Modulators with Inhibitory Effects on the ATR-Chk-1 Pathway

Y Yang, M Zhou, D Wang, X Liu, X Ye… - Journal of Natural …, 2021 - ACS Publications
Twelve undescribed jatrophane diterpenoids, euphpepluones A–L (1–12), together with
seven known analogues (13–19), were isolated from the whole plant of Euphorbia peplus …

The role of ingenane diterpenes in cancer therapy: From bioactive secondary compounds to small molecules

ALV Alves, LS da Silva, CA Faleiros… - Natural Product …, 2022 - journals.sagepub.com
Diterpenes are a class of critical taxonomic markers of the Euphorbiaceae family,
representing small compounds (eg, molecules) with a wide range of biological activities and …

Tri- and Diterpenoids from Stillingia loranthacea as Inhibitors of Zika Virus Replication

LS Abreu, YM do Nascimento, RS Costa… - Journal of natural …, 2019 - ACS Publications
This study represents the first phytochemical analysis of Stillingia loranthacea (S.
loranthacea) and describes new terpenoids obtained from the root bark of this species. The …