There has been a rapid increase in the number and demand for approved
biopharmaceuticals produced from animal cell culture processes over the last few years. In …

Cancer is the second leading cause of death in the industrialized world. Most cancer
patients are treated by a combination of surgery, radiation and/or chemotherapy. Whereas …

Techniques to analyze and sort single cells based on functional outputs, such as secreted
products, have the potential to transform our understanding of cellular biology as well as …

The present invention relates to nucleic acids encoding anti-CD20 antigen binding
molecules (ABMs). In particular embodiments, the present invention relates to nucleic acid …

Engineering robust microbes for the biotech industry typically requires high-level, genetically
stable expression of heterologous genes and pathways. Although plasmids have been used …

Recombinant biotherapeutic proteins such as monoclonal antibodies are mostly produced in
Chinese hamster ovary (CHO) cells and pharmaceutical companies are interested in an …

The selection of high-producing mammalian cell lines represents a bottleneck in process
development for the production of biopharmaceuticals. Traditional methods are time …

Therapeutic glycoproteins have played a major role in the commercial success of
biotechnology in the post-genomic era. But isolating recombinant mammalian cell lines for …

Previous work has shown that a human‐antibody‐producing recombinant CHO cell line did
not increase its intracellular content of protein disulfide isomerase (PDI) and heavy chain …

Chinese hamster ovarian cells (CHO) cells have been extensively utilized for industrial
production of biopharmaceutical products, such as monoclonal antibodies, human growth …