Drug-induced cardiotoxicity not only leads to the attrition of drugs during development, but
also contributes to the high morbidity and mortality rates of cardiovascular diseases …

Metformin is widely used to treat hyperglycemia in individuals with type 2 diabetes. Recently
the LKB1/AMP-activated protein kinase (LKB1/AMPK) pathway was proposed to mediate the …

Type 2 diabetes (T2D) is characterized by persistent hyperglycemia despite
hyperinsulinemia, affects more than 400 million people worldwide, and is a major cause of …

Background and Purpose Recent reports have suggested that salidroside could protect
cardiomyocytes from oxidative injury and stimulate glucose uptake in skeletal muscle cells …

Reversible and sub-lethal stresses to the mitochondria elicit a program of compensatory
responses that ultimately improve mitochondrial function, a conserved anti-aging …

Intracellular accumulation of wild type tau is a hallmark of sporadic Alzheimer's disease
(AD). However, the molecular mechanisms underlying tau toxicity is not fully understood …

The mechanisms by which metformin (dimethylbiguanide) inhibits hepatic gluconeogenesis
at concentrations relevant for type 2 diabetes therapy remain debated. Two proposed …

Peroxisome proliferator–activated receptor-γ coactivator-1α (PGC-1α) has been shown to
influence energy metabolism. Hence, we explored a strategy to target PGC-1α expression to …

Radiation-induced tumor cells death is the theoretical basis of tumor radiotherapy. Death
signaling disorder is the most important factor for radioresistance. However, the signaling …

Myoblast proliferation following myotrauma is regulated by multiple factors including growth
factors, signal pathways, transcription factors, and miRNAs. However, the molecular …