Alzheimer's and Parkinson's disease therapies in the clinic

P Chopade, N Chopade, Z Zhao… - Bioengineering & …, 2023 - Wiley Online Library
Alzheimer's disease (AD) and Parkinson's disease (PD) are the most prevalent
neurodegenerative diseases, affecting millions and costing billions each year in the United …

Sex differences in hippocampal cognition and neurogenesis

S Yagi, LAM Galea - Neuropsychopharmacology, 2019 - nature.com
Sex differences are reported in hippocampal plasticity, cognition, and in a number of
disorders that target the integrity of the hippocampus. For example, meta-analyses reveal …

OASIS-3: longitudinal neuroimaging, clinical, and cognitive dataset for normal aging and Alzheimer disease

PJ LaMontagne, TLS Benzinger, JC Morris, S Keefe… - medrxiv, 2019 - medrxiv.org
ABSTRACT OASIS-3 is a compilation of MRI and PET imaging and related clinical data for
1098 participants who were collected across several ongoing studies in the Washington …

Prospective longitudinal atrophy in Alzheimer's disease correlates with the intensity and topography of baseline tau-PET

R La Joie, AV Visani, SL Baker, JA Brown… - Science translational …, 2020 - science.org
β-Amyloid plaques and tau-containing neurofibrillary tangles are the two neuropathological
hallmarks of Alzheimer's disease (AD) and are thought to play crucial roles in a …

FreeSurfer

B Fischl - Neuroimage, 2012 - Elsevier
FreeSurfer is a suite of tools for the analysis of neuroimaging data that provides an array of
algorithms to quantify the functional, connectional and structural properties of the human …

Relationships of dietary patterns, foods, and micro-and macronutrients with Alzheimer's disease and late-life cognitive disorders: a systematic review

V Solfrizzi, C Custodero, M Lozupone… - Journal of …, 2017 - content.iospress.com
In the last decade, the association between diet and cognitive function or dementia has
been largely investigated. In the present article, we systematically reviewed observational …

Within-subject template estimation for unbiased longitudinal image analysis

M Reuter, NJ Schmansky, HD Rosas, B Fischl - Neuroimage, 2012 - Elsevier
Longitudinal image analysis has become increasingly important in clinical studies of normal
aging and neurodegenerative disorders. Furthermore, there is a growing appreciation of the …

Tracking pathophysiological processes in Alzheimer's disease: an updated hypothetical model of dynamic biomarkers

CR Jack, DS Knopman, WJ Jagust… - The lancet …, 2013 - thelancet.com
In 2010, we put forward a hypothetical model of the major biomarkers of Alzheimer's disease
(AD). The model was received with interest because we described the temporal evolution of …

[HTML][HTML] Alzheimer's disease profiled by fluid and imaging markers: tau PET best predicts cognitive decline

M Bucci, K Chiotis, A Nordberg… - Molecular …, 2021 - nature.com
For early detection of Alzheimer's disease, it is important to find biomarkers with predictive
value for disease progression and clinical manifestations, such as cognitive decline …

[HTML][HTML] Neuroimaging biomarkers for Alzheimer's disease

F Márquez, MA Yassa - Molecular neurodegeneration, 2019 - Springer
Currently, over five million Americans suffer with Alzheimer's disease (AD). In the absence of
a cure, this number could increase to 13.8 million by 2050. A critical goal of biomedical …