PM2. 5 particles in air pollution have been widely considered associated with respiratory
and cardiovascular diseases. Recent studies have shown that PM2. 5 can also cause …

Nitric oxide (NO) is a pleiotropic free radical messenger molecule. There is a large body of
evidence that the inducible form of the NO synthase enzyme (iNOS) that is responsible for …

Significance: Hydrogen sulfide is emerging as an important mediator of many aspects of
inflammation, and perhaps most importantly as a factor promoting the resolution of …

Resolution of inflammation is now recognized as a biosynthetically active process involving
pro-resolving mediators. Here, we show in zymosan-initiated peritoneal inflammation that …

Many studies have shown that genetic susceptibility plays a key role in determining whether
bacterial pathogens successfully infect and cause disease in potential hosts. Surprisingly …

The gut–brain axis refers to the bidirectional communication between the enteric nervous
system and the central nervous system. Mounting evidence supports the premise that the …

It is well established that central corticotropin releasing factor (CRF) signaling mediates the
gastrointestinal responses to stress. However, as shown in the brain, both CRF receptors …

The gut microbiota (formerly referred to as the gut flora) and its interactions, both symbiotic
and pathogenic, with the host, have become one of the hottest areas in biomedical science …

Pharmacological stabilization of hypoxia-inducible factor (HIF) through prolyl hydroxylase
(PHD) inhibition limits mucosal damage associated with models of murine colitis. However …

Celiac disease is a gluten intolerance caused by a T-cell response against human leukocyte
antigen (HLA)-DQ2 and DQ8-bound gluten peptides. Some subjects experience …