Highlights•Collision induced unfolding (CIU) uses gas phase activation to probe
biomolecules.•CIU can detect subtle changes in protein structure, stability or …

The structures and conformational dynamics of proteins, protein complexes, and their
noncovalent interactions with other molecules are controlled specifically by the Gibbs free …

Ion mobility spectrometry (IMS) coupled to mass spectrometry (MS) has seen spectacular
growth over the last two decades. Increasing IMS sensitivity and capacity with improvements …

The structure and folding of a protein in solution depends on noncovalent interactions within
the protein and those with surrounding ions and molecules. Decoupling these interactions in …

Due to their involvement in numerous biochemical pathways, neuropeptides have been the
focus of many recent research studies. Unfortunately, classic analytical methods, such as …

Donor–acceptor Stenhouse adducts (DASAs) are a new class of photoswitching molecules
with excellent fatigue resistance and synthetic tunability. Here, tandem ion mobility mass …

We report the first results from a new instrument capable of acquiring infrared spectra of
mobility-selected ions. This demonstration involves using ion mobility to first separate the …

The dynamic nature of intrinsically disordered peptides makes them a challenge to
characterize by solution-phase techniques. In order to gain insight into the relation between …

The top‐down approach in protein sequencing requires simple methods in which the
analyte can be readily dissociated at every position along the backbone. In this context …

An ion mobility mass spectrometry apparatus for investigating the photoisomerization and
photodissociation of electrosprayed molecular ions in the gas phase is described. The …