Chronic and cycling hypoxia: drivers of cancer chronic inflammation through HIF-1 and NF-κB activation: a review of the molecular mechanisms
J Korbecki, D Simińska… - International journal of …, 2021 - mdpi.com
Chronic (continuous, non-interrupted) hypoxia and cycling (intermittent, transient) hypoxia
are two types of hypoxia occurring in malignant tumors. They are both associated with the …
are two types of hypoxia occurring in malignant tumors. They are both associated with the …
Role of AMPK in autophagy
S Wang, H Li, M Yuan, H Fan, Z Cai - Frontiers in physiology, 2022 - frontiersin.org
Adenosine monophosphate-activated protein kinase (AMPK) is a significant energy sensor
in the maintenance of cellular energy homeostasis. Autophagy is a highly conserved …
in the maintenance of cellular energy homeostasis. Autophagy is a highly conserved …
Activation of AMPK under hypoxia: many roads leading to Rome
F Dengler - International journal of molecular sciences, 2020 - mdpi.com
AMP-activated protein kinase (AMPK) is known as a pivotal cellular energy sensor,
mediating the adaptation to low energy levels by deactivating anabolic processes and …
mediating the adaptation to low energy levels by deactivating anabolic processes and …
Zingerone reduces sodium arsenite-induced nephrotoxicity by regulating oxidative stress, inflammation, apoptosis and histopathological changes
Arsenic is widely available in the environment and arsenic toxicity is a public health problem
of serious concern worldwide. Zingerone is a promising phytochemical with various …
of serious concern worldwide. Zingerone is a promising phytochemical with various …
Strategic design of intelligent-responsive nanogel carriers for cancer therapy
Owing to the distinctive constituents of tumor tissue from those healthy organs,
nanomedicine strategies show significant potentials in smart drug delivery. Nowadays …
nanomedicine strategies show significant potentials in smart drug delivery. Nowadays …
AMPK: The key to ischemia‐reperfusion injury
J Cai, X Chen, X Liu, Z Li, A Shi, X Tang… - Journal of cellular …, 2022 - Wiley Online Library
Ischemia‐reperfusion injury (IRI) refers to a syndrome in which tissue damage is further
aggravated and organ function further deteriorates when blood flow is restored after a period …
aggravated and organ function further deteriorates when blood flow is restored after a period …
Fibronectin type III domain‐containing 5 improves aging‐related cardiac dysfunction in mice
C Hu, X Zhang, M Hu, T Teng, YP Yuan, P Song… - Aging …, 2022 - Wiley Online Library
Aging is an important risk factor for cardiovascular diseases, and aging‐related cardiac
dysfunction serves as a major determinant of morbidity and mortality in elderly populations …
dysfunction serves as a major determinant of morbidity and mortality in elderly populations …
Notoginsenoside R1 protects against myocardial ischemia/reperfusion injury in mice via suppressing TAK1-JNK/p38 signaling
J Zeng, H Shi, F Ren, X Zhao, Q Chen… - Acta Pharmacologica …, 2023 - nature.com
Previous studies show that notoginsenoside R1 (NG-R1), a novel saponin isolated from
Panax notoginseng, protects kidney, intestine, lung, brain and heart from ischemia …
Panax notoginseng, protects kidney, intestine, lung, brain and heart from ischemia …
Ephedra Herb extract ameliorates adriamycin-induced nephrotic syndrome in rats via the CAMKK2/AMPK/mTOR signaling pathway
Y Zhang, Z Mengnan, LI Benke, B Zhang… - Chinese Journal of …, 2023 - Elsevier
This study aimed to investigate the effect and mechanisms of Ephedra Herb (EH) extract on
adriamycin-induced nephrotic syndrome (NS), providing an experimental basis for the …
adriamycin-induced nephrotic syndrome (NS), providing an experimental basis for the …
[HTML][HTML] The dynamic interplay between AMPK/NFκB signaling and NLRP3 is a new therapeutic target in inflammation: Emerging role of dapagliflozin in overcoming …
Acute lung injury (ALI) is one the most common causes of morbidity and mortality in critically
ill patients. In this study, we examined for first time the role of dapagliflozin (DPGZ) in …
ill patients. In this study, we examined for first time the role of dapagliflozin (DPGZ) in …