Recent trends in biocatalysis

D Yi, T Bayer, CPS Badenhorst, S Wu… - Chemical Society …, 2021 - pubs.rsc.org
Biocatalysis has undergone revolutionary progress in the past century. Benefited by the
integration of multidisciplinary technologies, natural enzymatic reactions are constantly …

Cytochrome P450 enzymes in fungal natural product biosynthesis

X Zhang, J Guo, F Cheng, S Li - Natural Product Reports, 2021 - pubs.rsc.org
Covering: 2015 to the end of 2020 Fungal-derived polyketides, non-ribosomal peptides,
terpenoids and their hybrids contribute significantly to the chemical space of total natural …

De novo biosynthesis of bioactive isoflavonoids by engineered yeast cell factories

Q Liu, Y Liu, G Li, O Savolainen, Y Chen… - Nature …, 2021 - nature.com
Isoflavonoids comprise a class of plant natural products with great nutraceutical,
pharmaceutical and agricultural significance. Their low abundance in nature and structural …

Marine drugs: Biology, pipelines, current and future prospects for production

N Papon, BR Copp, V Courdavault - Biotechnology Advances, 2022 - Elsevier
The marine environment is a huge reservoir of biodiversity and represents an excellent
source of chemical compounds, some of which have large economical values. In the urgent …

Recent advances in the biosynthesis strategies of nitrogen heterocyclic natural products

B Gao, B Yang, X Feng, C Li - Natural Product Reports, 2022 - pubs.rsc.org
Covering: 2015 to 2020 Nitrogen heterocyclic natural products (NHNPs) are primary or
secondary metabolites containing nitrogen heterocyclic (N-heterocyclic) skeletons. Due to …

Screening non-conventional yeasts for acid tolerance and engineering Pichia occidentalis for production of muconic acid

ME Pyne, JA Bagley, L Narcross, K Kevvai… - Nature …, 2023 - nature.com
Saccharomyces cerevisiae is a workhorse of industrial biotechnology owing to the
organism's prominence in alcohol fermentation and the suite of sophisticated genetic tools …

De novo biosynthesis of berberine and halogenated benzylisoquinoline alkaloids in Saccharomyces cerevisiae

J Han, S Li - Communications Chemistry, 2023 - nature.com
Berberine is an extensively used pharmaceutical benzylisoquinoline alkaloid (BIA) derived
from plants. Microbial manufacturing has emerged as a promising approach to source …

Biosynthesis and synthetic biology of psychoactive natural products

CS Jamieson, J Misa, Y Tang… - Chemical Society Reviews, 2021 - pubs.rsc.org
Psychoactive natural products play an integral role in the modern world. The tremendous
structural complexity displayed by such molecules confers diverse biological activities of …

Biosynthesis of tetrahydropapaverine and semisynthesis of papaverine in yeast

OK Jamil, A Cravens, JT Payne… - Proceedings of the …, 2022 - National Acad Sciences
Tetrahydropapaverine (THP) and papaverine are plant natural products with clinically
significant roles. THP is a precursor in the production of the drugs atracurium and …

Construction of an l-Tyrosine Chassis in Pichia pastoris Enhances Aromatic Secondary Metabolite Production from Glycerol

R Kumokita, T Bamba, K Inokuma, T Yoshida… - ACS Synthetic …, 2022 - ACS Publications
Bioactive plant-based secondary metabolites such as stilbenoids, flavonoids, and
benzylisoquinoline alkaloids (BIAs) are produced from l-tyrosine (l-Tyr) and have a wide …