Genomic instability is a primary cause and fundamental feature of human cancer. However,
all cancer cell genotypes generally translate into several common pathophysiological …

Apoptosis, a type of genetically controlled cell death, is a fundamental cellular mechanism
utilized by multicellular organisms for disposal of cells that are no longer needed or …

Cells need to regulate their volume to counteract osmotic swelling or shrinkage, as well as
during cell division, growth, migration and cell death. Mammalian cells adjust their volume …

Fermentative organs such as the caecum, the colon, and the rumen have evolved to
produce and absorb energy rich short chain fatty acids (SCFA) from otherwise indigestible …

Phospholipid scrambling (PLS) is a ubiquitous cellular mechanism involving the regulated
bidirectional transport of phospholipids down their concentration gradient between …

Abstract Purinergic P2X7 receptors (P2X7R) are fundamental to innate immune response. In
macrophages, transient stimulation of P2X7R activates several transport mechanisms and …

The volume-regulated anion channel (VRAC), also known as the volume-sensitive
outwardly rectifying (VSOR) anion channel or the volume-sensitive organic osmolyte/anion …

Alzheimer's disease (AD) is a common form of dementia in aged people, which is defined by
two pathological characteristics: β-amyloid protein (Aβ) deposition and tau …

The volume‐regulated anion channel (VRAC) plays a pivotal role in cell volume regulation
in essentially all cell types studied. Additionally, VRAC appears to contribute importantly to a …

Before anoctamins (TMEM16 proteins) were identified as a family of Ca2+-activated chloride
channels and phospholipid scramblases, the founding member anoctamin 1 (ANO1 …