hdWGCNA identifies co-expression networks in high-dimensional transcriptomics data

S Morabito, F Reese, N Rahimzadeh, E Miyoshi… - Cell reports …, 2023 - cell.com
Biological systems are immensely complex, organized into a multi-scale hierarchy of
functional units based on tightly regulated interactions between distinct molecules, cells …

Retinal pathological features and proteome signatures of Alzheimer's disease

Y Koronyo, A Rentsendorj, N Mirzaei, GC Regis… - Acta …, 2023 - Springer
Alzheimer's disease (AD) pathologies were discovered in the accessible neurosensory
retina. However, their exact nature and topographical distribution, particularly in the early …

Sex specific molecular networks and key drivers of Alzheimer's disease

L Guo, J Cao, J Hou, Y Li, M Huang, L Zhu… - Molecular …, 2023 - Springer
Background Alzheimer's disease (AD) is a progressive and age-associated
neurodegenerative disorder that affects women disproportionally. However, the underlying …

Cryptic splicing of stathmin-2 and UNC13A mRNAs is a pathological hallmark of TDP-43-associated Alzheimer's disease

AR Agra Almeida Quadros, Z Li, X Wang… - Acta …, 2024 - Springer
Nuclear clearance and cytoplasmic accumulations of the RNA-binding protein TDP-43 are
pathological hallmarks in almost all patients with amyotrophic lateral sclerosis (ALS) and up …

FMNL2 regulates gliovascular interactions and is associated with vascular risk factors and cerebrovascular pathology in Alzheimer's disease

AJ Lee, NS Raghavan, P Bhattarai, T Siddiqui… - Acta …, 2022 - Springer
Alzheimer's disease (AD) has been associated with cardiovascular and cerebrovascular risk
factors (CVRFs) during middle age and later and is frequently accompanied by …

[HTML][HTML] Pursuit of precision medicine: Systems biology approaches in Alzheimer's disease mouse models

B Gurdon, C Kaczorowski - Neurobiology of disease, 2021 - Elsevier
Alzheimer's disease (AD) is a complex disease that is mediated by numerous factors and
manifests in various forms. A systems biology approach to studying AD involves analyses of …

The TMEM106B FTLD-protective variant, rs1990621, is also associated with increased neuronal proportion

Z Li, FHG Farias, U Dube, JL Del-Aguila… - Acta …, 2020 - Springer
Apart from amyloid β deposition and tau neurofibrillary tangles, Alzheimer's disease (AD) is
a neurodegenerative disorder characterized by neuronal loss and astrocytosis in the …

ABCA7-dependent induction of neuropeptide Y is required for synaptic resilience in Alzheimer's disease through BDNF/NGFR signaling

H Tayran, E Yilmaz, P Bhattarai, Y Min, X Wang, Y Ma… - Cell genomics, 2024 - cell.com
Genetic variants in ABCA7, an Alzheimer's disease (AD)-associated gene, elevate AD risk,
yet its functional relevance to the etiology is unclear. We generated a CRISPR-Cas9 …

TMEM106B coding variant is protective and deletion detrimental in a mouse model of tauopathy

GA Edwards III, CA Wood, Y He, Q Nguyen, PJ Kim… - Acta …, 2024 - Springer
TMEM106B is a risk modifier of multiple neurological conditions, where a single coding
variant and multiple non-coding SNPs influence the balance between susceptibility and …

A novel systems biology approach to evaluate mouse models of late-onset Alzheimer's disease

C Preuss, R Pandey, E Piazza, A Fine, A Uyar… - Molecular …, 2020 - Springer
Abstract Background Late-onset Alzheimer's disease (LOAD) is the most common form of
dementia worldwide. To date, animal models of Alzheimer's have focused on rare familial …