hdWGCNA identifies co-expression networks in high-dimensional transcriptomics data
Biological systems are immensely complex, organized into a multi-scale hierarchy of
functional units based on tightly regulated interactions between distinct molecules, cells …
functional units based on tightly regulated interactions between distinct molecules, cells …
Retinal pathological features and proteome signatures of Alzheimer's disease
Alzheimer's disease (AD) pathologies were discovered in the accessible neurosensory
retina. However, their exact nature and topographical distribution, particularly in the early …
retina. However, their exact nature and topographical distribution, particularly in the early …
Sex specific molecular networks and key drivers of Alzheimer's disease
Background Alzheimer's disease (AD) is a progressive and age-associated
neurodegenerative disorder that affects women disproportionally. However, the underlying …
neurodegenerative disorder that affects women disproportionally. However, the underlying …
Cryptic splicing of stathmin-2 and UNC13A mRNAs is a pathological hallmark of TDP-43-associated Alzheimer's disease
Nuclear clearance and cytoplasmic accumulations of the RNA-binding protein TDP-43 are
pathological hallmarks in almost all patients with amyotrophic lateral sclerosis (ALS) and up …
pathological hallmarks in almost all patients with amyotrophic lateral sclerosis (ALS) and up …
FMNL2 regulates gliovascular interactions and is associated with vascular risk factors and cerebrovascular pathology in Alzheimer's disease
Alzheimer's disease (AD) has been associated with cardiovascular and cerebrovascular risk
factors (CVRFs) during middle age and later and is frequently accompanied by …
factors (CVRFs) during middle age and later and is frequently accompanied by …
[HTML][HTML] Pursuit of precision medicine: Systems biology approaches in Alzheimer's disease mouse models
B Gurdon, C Kaczorowski - Neurobiology of disease, 2021 - Elsevier
Alzheimer's disease (AD) is a complex disease that is mediated by numerous factors and
manifests in various forms. A systems biology approach to studying AD involves analyses of …
manifests in various forms. A systems biology approach to studying AD involves analyses of …
The TMEM106B FTLD-protective variant, rs1990621, is also associated with increased neuronal proportion
Apart from amyloid β deposition and tau neurofibrillary tangles, Alzheimer's disease (AD) is
a neurodegenerative disorder characterized by neuronal loss and astrocytosis in the …
a neurodegenerative disorder characterized by neuronal loss and astrocytosis in the …
ABCA7-dependent induction of neuropeptide Y is required for synaptic resilience in Alzheimer's disease through BDNF/NGFR signaling
H Tayran, E Yilmaz, P Bhattarai, Y Min, X Wang, Y Ma… - Cell genomics, 2024 - cell.com
Genetic variants in ABCA7, an Alzheimer's disease (AD)-associated gene, elevate AD risk,
yet its functional relevance to the etiology is unclear. We generated a CRISPR-Cas9 …
yet its functional relevance to the etiology is unclear. We generated a CRISPR-Cas9 …
TMEM106B coding variant is protective and deletion detrimental in a mouse model of tauopathy
TMEM106B is a risk modifier of multiple neurological conditions, where a single coding
variant and multiple non-coding SNPs influence the balance between susceptibility and …
variant and multiple non-coding SNPs influence the balance between susceptibility and …
A novel systems biology approach to evaluate mouse models of late-onset Alzheimer's disease
Abstract Background Late-onset Alzheimer's disease (LOAD) is the most common form of
dementia worldwide. To date, animal models of Alzheimer's have focused on rare familial …
dementia worldwide. To date, animal models of Alzheimer's have focused on rare familial …