Toward the development of epigenome editing-based therapeutics: potentials and challenges

J Ueda, T Yamazaki, H Funakoshi - International Journal of Molecular …, 2023 - mdpi.com
The advancement in epigenetics research over the past several decades has led to the
potential application of epigenome-editing technologies for the treatment of various …

Epigenetic Therapies in Triple-Negative Breast Cancer: Concepts, Visions, and Challenges

U Lehmann - Cancers, 2024 - mdpi.com
Simple Summary Triple-negative breast cancer is an aggressive subtype of this frequent
malignancy in women, for which new therapeutic options are urgently needed. Changes in …

Comparative ethical evaluation of epigenome editing and genome editing in medicine: first steps and future directions

K Alex, EC Winkler - Journal of Medical Ethics, 2024 - jme.bmj.com
Targeted modifications of the human epigenome, epigenome editing (EE), are around the
corner. For EE, techniques similar to genome editing (GE) techniques are used. While in GE …

Is epigenome editing non-inheritable? Implications for ethics and the regulation of human applications

M Sasaki-Honda, K Akatsuka, T Sawai - Stem Cell Reports, 2023 - cell.com
Epigenome editing offers ethical advantages with non-inheritable gene expression control.
However, concerns arise regarding potential transgenerational effects in humans. Ethical …

The invisible hand: How epigenetics shapes CAR T cell destiny

A Ali, Y Zhang, J DiPersio - Molecular Therapy, 2024 - cell.com
Chimeric antigen receptor (CAR) T cell therapy has emerged as a revolutionary approach in
cancer immunotherapy, marking a significant advancement with the approval of multiple …

Is Dupras and Bunnik's framework for assessing privacy risks in multi-omic research and databases still too exceptionalist?

K Alex, EC Winkler - The American Journal of Bioethics, 2021 - Taylor & Francis
Dupras and Bunnik's (2021) strong statement against the normative approach of genetic
exceptionalism, which can no longer be justified in the midst of multi-omic research, is of …

Auditing the editor: a review of key translational issues in epigenetic editing

K Huerne, N Palmour, AR Wu, S Beck, A Berner… - The CRISPR …, 2022 - liebertpub.com
Currently, most advances in site-specific epigenetic editing for human use are concentrated
in basic research, yet, there is considerable interest to translate this technology beyond the …

The Ethical Dilemmas Epigenetic Editing In Utero Presents to Christians

V Hendrix - 2023 - digitalcommons.liberty.edu
The development of CRISPR epigenetic editing technology was initially impactful due to its
potential for disease treatment. However, despite the potential benefits of epigenetic …

Chapitre 15. Quelques enjeux éthiques, légaux et sociétaux que soulèvent les avancées en épigénétique

M Trousselard - Epigénétique et santé psychologique, 2024 - shs.cairn.info
Chapitre 15. Quelques enjeux éthiques, légaux et sociétaux que soulèvent les avancées en
épigénétique. In: Epigénétique et santé psychologique Fondements, processus et thérapies …

[HTML][HTML] crispr-cas9: el debate bioético más allá de la línea germinal

DV Infante-López, MF Céspedes-Galvis… - Persona y …, 2021 - scielo.org.co
El sistema CRISPR-Cas9 es una tecnología de edición genética que, además de ampliar
las posibilidades en investigación científica, despierta reflexiones asociadas a la dignidad …