PLK1 is an evolutionary conserved Ser/Thr kinase that is best known for its role in cell cycle
regulation and is expressed predominantly during the G2/S and M phase of the cell cycle …

Members of the polo-like kinase (PLK) family are crucial regulators of cell cycle progression,
centriole duplication, mitosis, cytokinesis and the DNA damage response. PLKs undergo …

Cancer remains to be one of the leading causes of death in the United States and around
the world. The advent of modern drug-targeted therapies has undeniably improved cancer …

Large numbers of inhibitors for polo-like kinases and aurora kinases are currently being
evaluated as anticancer drugs. Interest in these drugs is fuelled by the idea that these …

Coordinated progression through the cell cycle is a complex challenge for eukaryotic cells.
Following genotoxic stress, diverse molecular signals must be integrated to establish …

The microtubule-organizing activity of the centrosome oscillates during the cell cycle,
reaching its highest level at mitosis. At the onset of mitosis, the centrosome undergoes …

Vertebrate cells can initiate ciliogenesis from centrioles at the cell center, near the Golgi,
forming primary cilia confined or submerged in a deep narrow pit created by membrane …

Coordinated beating of cilia in the trachea generates a directional flow of mucus required to
clear the airways. Each cilium originates from a barrel-shaped basal body, from the side of …

During cell division, duplicated genetic material is separated into two distinct daughter cells.
This process is essential for initial tissue formation during development and to maintain …

Bioactive compounds are crucial for an extensive range of therapeutic uses, and some
exhibit anticancer activity. Scientists advocate that phytochemicals modulate autophagy and …