Protease biology is intimately linked to the functional consequences of substrate cleavage
events. Human caspases are a family of 12 fate-determining cysteine proteases that are best …

Cryptic MHC I-associated peptides (MAPs) are produced via two mechanisms: translation of
protein-coding genes in non-canonical reading frames and translation of allegedly non …

The myeloma surface proteome (surfaceome) determines tumor interaction with the
microenvironment and serves as an emerging arena for therapeutic development. Here, we …

Subtiligase-catalyzed peptide ligation is a powerful approach for site-specific protein
bioconjugation, synthesis and semisynthesis of proteins and peptides, and chemoproteomic …

Although individual pseudogenes have been implicated in tumour biology, the biomedical
significance and clinical relevance of pseudogene expression have not been assessed in a …

Protein post-translational modifications (PTMs), which are usually enzymatically catalyzed,
are major regulators of protein activity and involved in almost all celluar processes …

Background Oxygen and glucose metabolism play pivotal roles in many (patho)
physiological conditions. In particular, oxygen and glucose deprivation (OGD) during …

Next-generation sequencing (NGS) technologies have greatly expanded the size of the
known transcriptome. Many newly discovered transcripts are classified as long noncoding …

Apoptosis, in contrast to other forms of cell death such as necrosis, was originally regarded
as a 'silent'mechanism of cell elimination designed to degrade the contents of doomed cells …

Ribosome profiling is a technique that permits genome-wide, quantitative analysis of
translation and has found broad application in recent years. Here we describe a modified …