Mutations in the genes encoding Leucine Rich Repeat (LRR) containing proteins are
associated with over sixty human diseases; these include high myopia, mitochondrial …

The gonadotropin receptors LH receptor and FSH receptor play a central role in governing
reproductive competency/fertility. Gonadotropin hormone analogs have been used clinically …

The protostome leucokinin (LK) signaling system, including LK peptides and their G protein-
coupled receptors, has been characterized in several species. Despite the progress …

This narrative review is concerned with genetic variants of the genes encoding
gonadotrophin subunits and their receptors, as well as their implications into the diagnosis …

The follicle-stimulating hormone receptor (FSHR) has been targeted therapeutically for
decades, due to its pivotal role in reproduction. To date, only purified and …

Signal transduction by luteinizing hormone receptors (LHRs) and follicle-stimulating
hormone receptors (FSHRs) is essential for the successful reproduction of human beings …

Purpose To screen novel mutations in LHCGR responsible for empty follicle syndrome and
explore the pathological mechanism of mutations. Methods Four affected individuals …

Mutations in G protein-coupled receptors (GPCRs) underlie numerous diseases. Many
cause receptor misfolding and failure to reach the cell surface. Pharmacological chaperones …

Misfolding of G protein-coupled receptors (GPCRs) caused by mutations frequently leads to
disease due to intracellular trapping of the conformationally abnormal receptor. Several …

Diversity, a hallmark of G protein-coupled receptor (GPCR) signaling, partly stems from
alternative splicing of a single gene generating more than one isoform for a receptor …