The implementation of imaging technologies has dramatically increased the efficiency of
preclinical studies, enabling a powerful, non-invasive and clinically translatable way for …

Tau protein accumulation is the most common pathology among degenerative brain
diseases, including Alzheimer's disease (AD), progressive supranuclear palsy (PSP) …

Recent clinical data indicates that hemodynamic changes caused by cardiovascular
diseases such as atherosclerosis, heart failure, and hypertension affect cognition. Yet, the …

Vascular pathology is a major feature of Alzheimer's disease (AD) and other dementias. We
recently showed that chronic administration of the target-of-rapamycin (TOR) inhibitor …

Effective drug delivery in brain tumors remains a major challenge in oncology. Although
local hyperthermia and stimuli-responsive delivery systems, such as thermosensitive …

Purpose.: To investigate ocular blood flow and visual function in the Ins2 Akita diabetic
retinopathy mouse model at early and late time points after onset of hyperglycemia …

Magnetic nanoparticles have garnered sustained research interest for their promise in
biomedical applications including diagnostic imaging, triggered drug release, cancer …

Alterations to the cerebral microcirculation have been recognized to play a crucial role in the
development of neurodegenerative disorders. However, the exact role of the microvascular …

High field MRI has been applied to high-resolution structural and functional imaging of the
brain. Echo planar imaging (EPI) is an ultrafast acquisition technique widely used in …

Mild traumatic brain injury (mTBI) has been shown to acutely alter the gut microbiome
diversity and composition, known as dysbiosis, which can further exacerbate metabolic and …