Although cancer is a diverse set of diseases, cancer cells share a number of adaptive
hallmarks. Dysregulated pH is emerging as a hallmark of cancer because cancers show …

The rapid proliferation of cancer cells combined with deficient vessels cause regions of
nutrient and O2 deprivation in solid tumors. Some cancer cells can adapt to these extreme …

Cancer immunotherapies, such as immune checkpoint blockade or adoptive T-cell transfer,
can lead to durable responses in the clinic, but response rates remain low due to undefined …

Tumor hypoxia is a well-established biological phenomenon that affects the curability of
solid tumors, regardless of treatment modality. Especially for head and neck cancer patients …

Oxygen deprivation (hypoxia) in non–small cell lung cancer (NSCLC) is an important factor
in treatment resistance and poor survival. Hypoxia is an attractive therapeutic target …

The tumor microenvironment includes a complicated network of physiological gradients
contributing to plasticity of tumor cells and heterogeneity of tumor tissue. Hypoxia is a key …

Carbonic anhydrase IX (CAIX) is a hypoxia-inducible enzyme that is overexpressed by
cancer cells from many tumor types, and is a component of the pH regulatory system …

Following the identification of a set of hypoxia-regulated microRNAs (miRNAs), recent
studies have highlighted the importance of miR-210 and of its transcriptional regulation by …

A distinguishing phenotype of solid tumors is the presence of an alkaline cellular feature
despite the surrounding acidic microenvironment. This phenotypic characteristic of tumors …

Cancer cells undergo genetic changes allowing their adaptation to environmental changes,
thereby obtaining an advantage during the long metastatic route, disseminated of several …