Accumulating evidence reveals that metabolic and cell survival pathways are closely
related, sharing common signaling molecules. Hexokinase catalyzes the phosphorylation of …

Cancer is a disease characterized by unrestrained cellular proliferation. In order to sustain
growth, cancer cells undergo a complex metabolic rearrangement characterized by changes …

Background Pyroptosis is a lytic cell death form executed by gasdermins family proteins.
Induction of tumor pyroptosis promotes anti-tumor immunity and is a potential cancer …

Cancer cells alter their metabolism for the production of precursors of macromolecules.
However, the control mechanisms underlying this reprogramming are poorly understood …

The mammalian target of rapamycin complex 1 (mTORC1) regulates activation of immune
cells and cellular energy metabolism. Although glycolysis has been linked to immune …

The altered metabolism of tumors has been considered a target for anticancer therapy.
However, the relationship between distinct tumor-initiating lesions and anomalies of tumor …

Background Human pluripotent stem cells have the ability to generate all cell types present
in the adult organism, therefore harboring great potential for the in vitro study of …

Tumor formation and growth depend on various biological metabolism processes that are
distinctly different with normal tissues. Abnormal energy metabolism is one of the typical …

Eukaryotic mitochondria resulted from symbiotic incorporation of α-proteobacteria into
ancient archaea species. During evolution, mitochondria lost most of the prokaryotic …

During the last decades a considerable amount of research has been focused on cancer.
Recently, tumor cell metabolism has been considered as a possible target for cancer …