Hexokinase II integrates energy metabolism and cellular protection: Akting on mitochondria and TORCing to autophagy
DJ Roberts, S Miyamoto - Cell Death & Differentiation, 2015 - nature.com
Accumulating evidence reveals that metabolic and cell survival pathways are closely
related, sharing common signaling molecules. Hexokinase catalyzes the phosphorylation of …
related, sharing common signaling molecules. Hexokinase catalyzes the phosphorylation of …
[HTML][HTML] Dysregulated metabolism contributes to oncogenesis
MD Hirschey, RJ DeBerardinis, AME Diehl… - Seminars in cancer …, 2015 - Elsevier
Cancer is a disease characterized by unrestrained cellular proliferation. In order to sustain
growth, cancer cells undergo a complex metabolic rearrangement characterized by changes …
growth, cancer cells undergo a complex metabolic rearrangement characterized by changes …
Natural product triptolide induces GSDME-mediated pyroptosis in head and neck cancer through suppressing mitochondrial hexokinase-ΙΙ
J Cai, M Yi, Y Tan, X Li, G Li, Z Zeng, W Xiong… - Journal of Experimental …, 2021 - Springer
Background Pyroptosis is a lytic cell death form executed by gasdermins family proteins.
Induction of tumor pyroptosis promotes anti-tumor immunity and is a potential cancer …
Induction of tumor pyroptosis promotes anti-tumor immunity and is a potential cancer …
Global metabolic reprogramming of colorectal cancer occurs at adenoma stage and is induced by MYC
K Satoh, S Yachida, M Sugimoto… - Proceedings of the …, 2017 - National Acad Sciences
Cancer cells alter their metabolism for the production of precursors of macromolecules.
However, the control mechanisms underlying this reprogramming are poorly understood …
However, the control mechanisms underlying this reprogramming are poorly understood …
[PDF][PDF] RETRACTED: mTORC1-induced HK1-dependent glycolysis regulates NLRP3 inflammasome activation
JS Moon, S Hisata, MA Park, GM DeNicola, SW Ryter… - Cell reports, 2015 - cell.com
The mammalian target of rapamycin complex 1 (mTORC1) regulates activation of immune
cells and cellular energy metabolism. Although glycolysis has been linked to immune …
cells and cellular energy metabolism. Although glycolysis has been linked to immune …
The metabolic profile of tumors depends on both the responsible genetic lesion and tissue type
MO Yuneva, TWM Fan, TD Allen, RM Higashi… - Cell metabolism, 2012 - cell.com
The altered metabolism of tumors has been considered a target for anticancer therapy.
However, the relationship between distinct tumor-initiating lesions and anomalies of tumor …
However, the relationship between distinct tumor-initiating lesions and anomalies of tumor …
Energy metabolism in human pluripotent stem cells and their differentiated counterparts
S Varum, AS Rodrigues, MB Moura, O Momcilovic… - PloS one, 2011 - journals.plos.org
Background Human pluripotent stem cells have the ability to generate all cell types present
in the adult organism, therefore harboring great potential for the in vitro study of …
in the adult organism, therefore harboring great potential for the in vitro study of …
Tumor energy metabolism and potential of 3-bromopyruvate as an inhibitor of aerobic glycolysis: implications in tumor treatment
T Fan, G Sun, X Sun, L Zhao, R Zhong, Y Peng - Cancers, 2019 - mdpi.com
Tumor formation and growth depend on various biological metabolism processes that are
distinctly different with normal tissues. Abnormal energy metabolism is one of the typical …
distinctly different with normal tissues. Abnormal energy metabolism is one of the typical …
Mitochondrial regulation of cell cycle and proliferation
VG Antico Arciuch, ME Elguero… - Antioxidants & redox …, 2012 - liebertpub.com
Eukaryotic mitochondria resulted from symbiotic incorporation of α-proteobacteria into
ancient archaea species. During evolution, mitochondria lost most of the prokaryotic …
ancient archaea species. During evolution, mitochondria lost most of the prokaryotic …
[HTML][HTML] The Warburg and Crabtree effects: On the origin of cancer cell energy metabolism and of yeast glucose repression
R Diaz-Ruiz, M Rigoulet, A Devin - Biochimica et Biophysica Acta (BBA) …, 2011 - Elsevier
During the last decades a considerable amount of research has been focused on cancer.
Recently, tumor cell metabolism has been considered as a possible target for cancer …
Recently, tumor cell metabolism has been considered as a possible target for cancer …