The sodium-dependent ascorbic acid transporter family SLC23

M Bürzle, Y Suzuki, D Ackermann, H Miyazaki… - Molecular aspects of …, 2013 - Elsevier
Transporters for vitamin C and its oxidized form dehydroascorbic acid (DHA) are crucial to
maintain physiological concentrations of this important vitamin that is used in a variety of …

Functional and physiological role of vitamin C transporters

M Bürzle, MA Hediger - Current topics in membranes, 2012 - Elsevier
Vitamin C (ascorbic acid) is required for the synthesis of collagen, carnitine, catecholamine
and the neurotransmitter norepinephrine. Vitamin C also plays an important role in …

Vitamin C deficiency in the brain impairs cognition, increases amyloid accumulation and deposition, and oxidative stress in APP/PSEN1 and normally aging mice

S Dixit, A Bernardo, JM Walker… - ACS chemical …, 2015 - ACS Publications
Subclinical vitamin C deficiency is widespread in many populations, but its role in both
Alzheimer's disease and normal aging is understudied. In the present study, we decreased …

[HTML][HTML] Human skeletal muscle ascorbate is highly responsive to changes in vitamin C intake and plasma concentrations

AC Carr, SM Bozonet, JM Pullar, JW Simcock… - The American journal of …, 2013 - Elsevier
Background: Vitamin C (ascorbate) is likely to be essential for skeletal muscle structure and
function via its role as an enzyme cofactor for collagen and carnitine biosynthesis. Vitamin C …

Ascorbic acid supplementation improves skeletal muscle oxidative stress and insulin sensitivity in people with type 2 diabetes: Findings of a randomized controlled …

SA Mason, PA Della Gatta, RJ Snow, AP Russell… - Free Radical Biology …, 2016 - Elsevier
Aim/hypothesis Skeletal muscle insulin resistance and oxidative stress are characteristic
metabolic disturbances in people with type 2 diabetes. Studies in insulin resistant rodents …

Dehydroascorbic acid promotes cell death in neurons under oxidative stress: a protective role for astrocytes

A García-Krauss, L Ferrada, A Astuya, K Salazar… - Molecular …, 2016 - Springer
Ascorbic acid (AA), the reduced form of vitamin C, is incorporated into neurons via the
sodium ascorbate co-transporter SVCT2. However, this transporter is not expressed in …

A Randomized Steady-State Bioavailability Study of Synthetic versus Natural (Kiwifruit-Derived) Vitamin C

AC Carr, SM Bozonet, JM Pullar, JW Simcock… - Nutrients, 2013 - mdpi.com
Whether vitamin C from wholefoods has equivalent bioavailability to a purified supplement
remains unclear. We have previously showed that kiwifruit provided significantly higher …

Effect of diabetes induction and exercisetraining on the level of ascorbic acid and muscle SVCT2 in male Wistar rats

A Ghalavand, P Motamedi… - Journal of Shahid …, 2020 - publish.kne-publishing.com
Introduction: Sodium-dependent vitamin C transporter 2 (SVCT2) plays an important role in
the transfer of ascorbic acid to slow-twitch fiber. The purpose of this study was investigating …

The sodium/ascorbic acid co-transporter SVCT2 distributes in a striated membrane-enriched domain at the M-band level in slow-twitch skeletal muscle fibers

D Sandoval, J Mella, J Ojeda, F Bermedo-García… - Biological Research, 2024 - Springer
Background Vitamin C plays key roles in cellular homeostasis, functioning as a potent
antioxidant and a positive regulator of cell differentiation. In skeletal muscle, the vitamin …

[HTML][HTML] The effect of six weeks aerobic training on Serum and muscle levels of ascorbic acid and SVCT2 of soleus muscle tissue in Wistar rats

A Ghalavand, P Motamedi, H Rajabi… - Jundishapur Scientific …, 2019 - jsmj.ajums.ac.ir
Introduction: Sodium-dependent vitamin C transporter 2 (SVCT2) plays an important role in
the transfer of ascorbic acid to slow-twitch fiber. Due to the importance of ascorbic acid in …