The sodium-dependent ascorbic acid transporter family SLC23
M Bürzle, Y Suzuki, D Ackermann, H Miyazaki… - Molecular aspects of …, 2013 - Elsevier
Transporters for vitamin C and its oxidized form dehydroascorbic acid (DHA) are crucial to
maintain physiological concentrations of this important vitamin that is used in a variety of …
maintain physiological concentrations of this important vitamin that is used in a variety of …
Functional and physiological role of vitamin C transporters
M Bürzle, MA Hediger - Current topics in membranes, 2012 - Elsevier
Vitamin C (ascorbic acid) is required for the synthesis of collagen, carnitine, catecholamine
and the neurotransmitter norepinephrine. Vitamin C also plays an important role in …
and the neurotransmitter norepinephrine. Vitamin C also plays an important role in …
Vitamin C deficiency in the brain impairs cognition, increases amyloid accumulation and deposition, and oxidative stress in APP/PSEN1 and normally aging mice
S Dixit, A Bernardo, JM Walker… - ACS chemical …, 2015 - ACS Publications
Subclinical vitamin C deficiency is widespread in many populations, but its role in both
Alzheimer's disease and normal aging is understudied. In the present study, we decreased …
Alzheimer's disease and normal aging is understudied. In the present study, we decreased …
[HTML][HTML] Human skeletal muscle ascorbate is highly responsive to changes in vitamin C intake and plasma concentrations
Background: Vitamin C (ascorbate) is likely to be essential for skeletal muscle structure and
function via its role as an enzyme cofactor for collagen and carnitine biosynthesis. Vitamin C …
function via its role as an enzyme cofactor for collagen and carnitine biosynthesis. Vitamin C …
Ascorbic acid supplementation improves skeletal muscle oxidative stress and insulin sensitivity in people with type 2 diabetes: Findings of a randomized controlled …
SA Mason, PA Della Gatta, RJ Snow, AP Russell… - Free Radical Biology …, 2016 - Elsevier
Aim/hypothesis Skeletal muscle insulin resistance and oxidative stress are characteristic
metabolic disturbances in people with type 2 diabetes. Studies in insulin resistant rodents …
metabolic disturbances in people with type 2 diabetes. Studies in insulin resistant rodents …
Dehydroascorbic acid promotes cell death in neurons under oxidative stress: a protective role for astrocytes
Ascorbic acid (AA), the reduced form of vitamin C, is incorporated into neurons via the
sodium ascorbate co-transporter SVCT2. However, this transporter is not expressed in …
sodium ascorbate co-transporter SVCT2. However, this transporter is not expressed in …
A Randomized Steady-State Bioavailability Study of Synthetic versus Natural (Kiwifruit-Derived) Vitamin C
Whether vitamin C from wholefoods has equivalent bioavailability to a purified supplement
remains unclear. We have previously showed that kiwifruit provided significantly higher …
remains unclear. We have previously showed that kiwifruit provided significantly higher …
Effect of diabetes induction and exercisetraining on the level of ascorbic acid and muscle SVCT2 in male Wistar rats
A Ghalavand, P Motamedi… - Journal of Shahid …, 2020 - publish.kne-publishing.com
Introduction: Sodium-dependent vitamin C transporter 2 (SVCT2) plays an important role in
the transfer of ascorbic acid to slow-twitch fiber. The purpose of this study was investigating …
the transfer of ascorbic acid to slow-twitch fiber. The purpose of this study was investigating …
The sodium/ascorbic acid co-transporter SVCT2 distributes in a striated membrane-enriched domain at the M-band level in slow-twitch skeletal muscle fibers
D Sandoval, J Mella, J Ojeda, F Bermedo-García… - Biological Research, 2024 - Springer
Background Vitamin C plays key roles in cellular homeostasis, functioning as a potent
antioxidant and a positive regulator of cell differentiation. In skeletal muscle, the vitamin …
antioxidant and a positive regulator of cell differentiation. In skeletal muscle, the vitamin …
[HTML][HTML] The effect of six weeks aerobic training on Serum and muscle levels of ascorbic acid and SVCT2 of soleus muscle tissue in Wistar rats
Introduction: Sodium-dependent vitamin C transporter 2 (SVCT2) plays an important role in
the transfer of ascorbic acid to slow-twitch fiber. Due to the importance of ascorbic acid in …
the transfer of ascorbic acid to slow-twitch fiber. Due to the importance of ascorbic acid in …