Radiochemistry for positron emission tomography

J Rong, A Haider, TE Jeppesen, L Josephson… - Nature …, 2023 - nature.com
Positron emission tomography (PET) constitutes a functional imaging technique that is
harnessed to probe biological processes in vivo. PET imaging has been used to diagnose …

Chemistry for Positron Emission Tomography: Recent Advances in 11C‐, 18F‐, 13N‐, and 15O‐Labeling Reactions

X Deng, J Rong, L Wang, N Vasdev… - Angewandte Chemie …, 2019 - Wiley Online Library
Positron emission tomography (PET) is a molecular imaging technology that provides
quantitative information about function and metabolism in biological processes in vivo for …

[HTML][HTML] Recent developments on PET radiotracers for TSPO and their applications in neuroimaging

L Zhang, K Hu, T Shao, L Hou, S Zhang, W Ye… - … Pharmaceutica Sinica B, 2021 - Elsevier
The 18 kDa translocator protein (TSPO), previously known as the peripheral
benzodiazepine receptor, is predominately localized to the outer mitochondrial membrane in …

18F-Fluorination: Challenge and Opportunity for Organic Chemists

R Halder, T Ritter - The Journal of Organic Chemistry, 2021 - ACS Publications
18F-fluorination is an important and growing field in organic synthesis that has attracted
many chemists in the recent past. Here we present our own, biased perspective with a focus …

Derisking the Cu-Mediated 18F-Fluorination of Heterocyclic Positron Emission Tomography Radioligands

NJ Taylor, E Emer, S Preshlock… - Journal of the …, 2017 - ACS Publications
Molecules labeled with fluorine-18 (18F) are used in positron emission tomography to
visualize, characterize and measure biological processes in the body. Despite recent …

Copper-Mediated Radiofluorination of Arylstannanes with [18F]KF

KJ Makaravage, AF Brooks, AV Mossine… - Organic …, 2016 - ACS Publications
A copper-mediated nucleophilic radiofluorination of aryl-and vinylstannanes with [18F] KF is
described. This method is fast, uses commercially available reagents, and is compatible with …

Divergent C (sp 2)–H arylation of heterocycles via organic photoredox catalysis

J Ren, C Pi, X Cui, Y Wu - Green Chemistry, 2022 - pubs.rsc.org
Introducing aryl moieties into heterocyclic scaffolds is a key step in the syntheses of natural
products, drugs, and functional materials. Herein, we describe an unprecedented …

Recent progress in the application of iodonium ylides in organic synthesis

X Mi, C Pi, W Feng, X Cui - Organic Chemistry Frontiers, 2022 - pubs.rsc.org
Iodonium ylides have attracted considerable attention due to their unique properties and
numerous applications as versatile and sustainable reagents in organic synthesis …

Rhodium(III)‐Catalyzed Divergent C−H Functionalization of N‐Aryl Amidines with Iodonium Ylides: Access to Carbazolones and Zwitterionic Salts

J Ren, L Yang, C Pi, X Cui, Y Wu - Advanced Synthesis & …, 2023 - Wiley Online Library
We described an Rhodium (III)‐catalyzed divergent C− H bond functionalization of N‐aryl
amidines with iodonium ylides. Carbazolones and zwitterionic salts were diversely …

Cu-Mediated C–H 18F-Fluorination of Electron-Rich (Hetero)arenes

MS McCammant, S Thompson, AF Brooks… - Organic …, 2017 - ACS Publications
This communication describes a method for the nucleophilic radiofluorination of electron-
rich arenes. The reaction involves the initial C (sp2)–H functionalization of an electron-rich …