Model of autism: increased ratio of excitation/inhibition in key neural systems

JLR Rubenstein, MM Merzenich - Genes, Brain and Behavior, 2003 - Wiley Online Library
Autism is a severe neurobehavioral syndrome, arising largely as an inherited disorder,
which can arise from several diseases. Despite recent advances in identifying some genes …

The genetics of autism

R Muhle, SV Trentacoste, I Rapin - Pediatrics, 2004 - publications.aap.org
Autism is a complex, behaviorally defined, static disorder of the immature brain that is of
great concern to the practicing pediatrician because of an astonishing 556% reported …

Genetics of austim: complex aetiology for a heterogeneous disorder

SE Folstein, B Rosen-Sheidley - Nature Reviews Genetics, 2001 - nature.com
Since autism was first recognized as a disorder in 1943, speculation about its aetiology has
ranged from biological to psychological and back again. After twin studies during the 1970s …

The genetics of autistic disorders and its clinical relevance: a review of the literature

CM Freitag - Molecular psychiatry, 2007 - nature.com
Twin and family studies in autistic disorders (AD) have elucidated a high heritability of the
narrow and broad phenotype of AD. In this review on the genetics of AD, we will initially …

Neurobiological effects of intraventricular propionic acid in rats: possible role of short chain fatty acids on the pathogenesis and characteristics of autism spectrum …

DF MacFabe, DP Cain, K Rodriguez-Capote… - Behavioural brain …, 2007 - Elsevier
Clinical observations suggest that certain gut and dietary factors may transiently worsen
symptoms in autism spectrum disorders (ASD), epilepsy and some inheritable metabolic …

[HTML][HTML] Serotonin transporter: gene, genetic disorders, and pharmacogenetics

DL Murphy, A Lerner, G Rudnick… - Molecular …, 2004 - triggered.edina.clockss.org
The highly evolutionarily conserved serotonin transporter (SERT) regulates the entire
serotoninergic system and its receptors via mod-ulation of extracellular fluid serotonin …

The contributions of oxytocin and vasopressin pathway genes to human behavior

RP Ebstein, A Knafo, D Mankuta, SH Chew… - Hormones and …, 2012 - Elsevier
Arginine vasopressin (AVP) and oxytocin (OXT) are social hormones and mediate affiliative
behaviors in mammals and as recently demonstrated, also in humans. There is intense …

Neurochemical correlates of autistic disorder: a review of the literature

KSL Lam, MG Aman, LE Arnold - Research in developmental disabilities, 2006 - Elsevier
Review of neurochemical investigations in autistic disorder revealed that a wide array of
transmitter systems have been studied, including serotonin, dopamine, norepinephrine …

No gene is an island: the flip-flop phenomenon

PI Lin, JM Vance, MA Pericak-Vance… - The American Journal of …, 2007 - cell.com
An increasing number of publications are replicating a previously reported disease-marker
association but with the risk allele reversed from the previous report. Do such" flip-flop" …

Allelic heterogeneity at the serotonin transporter locus (SLC6A4) confers susceptibility to autism and rigid-compulsive behaviors

JS Sutcliffe, RJ Delahanty, HC Prasad… - The American Journal of …, 2005 - cell.com
Autism is a spectrum of neurodevelopmental disorders with a primarily genetic etiology
exhibiting deficits in (1) development of language and (2) social relationships and (3) …