Model of autism: increased ratio of excitation/inhibition in key neural systems
JLR Rubenstein, MM Merzenich - Genes, Brain and Behavior, 2003 - Wiley Online Library
Autism is a severe neurobehavioral syndrome, arising largely as an inherited disorder,
which can arise from several diseases. Despite recent advances in identifying some genes …
which can arise from several diseases. Despite recent advances in identifying some genes …
The genetics of autism
R Muhle, SV Trentacoste, I Rapin - Pediatrics, 2004 - publications.aap.org
Autism is a complex, behaviorally defined, static disorder of the immature brain that is of
great concern to the practicing pediatrician because of an astonishing 556% reported …
great concern to the practicing pediatrician because of an astonishing 556% reported …
Genetics of austim: complex aetiology for a heterogeneous disorder
SE Folstein, B Rosen-Sheidley - Nature Reviews Genetics, 2001 - nature.com
Since autism was first recognized as a disorder in 1943, speculation about its aetiology has
ranged from biological to psychological and back again. After twin studies during the 1970s …
ranged from biological to psychological and back again. After twin studies during the 1970s …
The genetics of autistic disorders and its clinical relevance: a review of the literature
CM Freitag - Molecular psychiatry, 2007 - nature.com
Twin and family studies in autistic disorders (AD) have elucidated a high heritability of the
narrow and broad phenotype of AD. In this review on the genetics of AD, we will initially …
narrow and broad phenotype of AD. In this review on the genetics of AD, we will initially …
Neurobiological effects of intraventricular propionic acid in rats: possible role of short chain fatty acids on the pathogenesis and characteristics of autism spectrum …
DF MacFabe, DP Cain, K Rodriguez-Capote… - Behavioural brain …, 2007 - Elsevier
Clinical observations suggest that certain gut and dietary factors may transiently worsen
symptoms in autism spectrum disorders (ASD), epilepsy and some inheritable metabolic …
symptoms in autism spectrum disorders (ASD), epilepsy and some inheritable metabolic …
[HTML][HTML] Serotonin transporter: gene, genetic disorders, and pharmacogenetics
DL Murphy, A Lerner, G Rudnick… - Molecular …, 2004 - triggered.edina.clockss.org
The highly evolutionarily conserved serotonin transporter (SERT) regulates the entire
serotoninergic system and its receptors via mod-ulation of extracellular fluid serotonin …
serotoninergic system and its receptors via mod-ulation of extracellular fluid serotonin …
The contributions of oxytocin and vasopressin pathway genes to human behavior
Arginine vasopressin (AVP) and oxytocin (OXT) are social hormones and mediate affiliative
behaviors in mammals and as recently demonstrated, also in humans. There is intense …
behaviors in mammals and as recently demonstrated, also in humans. There is intense …
Neurochemical correlates of autistic disorder: a review of the literature
KSL Lam, MG Aman, LE Arnold - Research in developmental disabilities, 2006 - Elsevier
Review of neurochemical investigations in autistic disorder revealed that a wide array of
transmitter systems have been studied, including serotonin, dopamine, norepinephrine …
transmitter systems have been studied, including serotonin, dopamine, norepinephrine …
No gene is an island: the flip-flop phenomenon
PI Lin, JM Vance, MA Pericak-Vance… - The American Journal of …, 2007 - cell.com
An increasing number of publications are replicating a previously reported disease-marker
association but with the risk allele reversed from the previous report. Do such" flip-flop" …
association but with the risk allele reversed from the previous report. Do such" flip-flop" …
Allelic heterogeneity at the serotonin transporter locus (SLC6A4) confers susceptibility to autism and rigid-compulsive behaviors
JS Sutcliffe, RJ Delahanty, HC Prasad… - The American Journal of …, 2005 - cell.com
Autism is a spectrum of neurodevelopmental disorders with a primarily genetic etiology
exhibiting deficits in (1) development of language and (2) social relationships and (3) …
exhibiting deficits in (1) development of language and (2) social relationships and (3) …