Epithelial tight junctions define the paracellular permeability of the intestinal barrier.
Molecules can cross the tight junctions via two distinct size-selective and charge-selective …

Almost all currently available treatments for inflammatory bowel disease (IBD) act by
inhibiting inflammation, often blocking specific inflammatory molecules. However, given the …

A fundamental function of the intestinal epithelium is to act as a barrier that limits interactions
between luminal contents such as the intestinal microbiota, the underlying immune system …

Signaling pathways regulate contraction of striated (skeletal and cardiac) and smooth
muscle. Although these are similar, there are striking differences in the pathways that can be …

Cardiovascular disease is a leading cause of death worldwide and accounts for> 17.3
million deaths per year, with an estimated increase in incidence to 23.6 million by 2030 …

Background & Aims Tight junction dysregulation and epithelial damage contribute to barrier
loss in patients with inflammatory bowel disease. However, the mechanisms that regulate …

The importance of maintaining contractile function in aortic smooth muscle cells (SMCs) is
evident by the fact that heterozygous mutations in the major structural proteins or kinases …

Background The gastrointestinal motility is affected by gut microbiota and the relationship
between them has become a hot topic. However, mechanisms of microbiota in regulating …

The gut microbiota is involved in various physiological functions, and disturbances in the
host-microbiome have been proven to contribute to the dysfunction of gut; however, whether …

Defective epithelial barrier function is present in maladies including epidermal burn injury,
environmental lung damage, renal tubular disease, and a range of immune-mediated and …