[PDF][PDF] GDF15: a hormone conveying somatic distress to the brain
GDF15 has recently gained scientific and translational prominence with the discovery that its
receptor is a GFRAL-RET heterodimer of which GFRAL is expressed solely in the hindbrain …
receptor is a GFRAL-RET heterodimer of which GFRAL is expressed solely in the hindbrain …
Mechanotransduction in cardiac hypertrophy and failure
RC Lyon, F Zanella, JH Omens, F Sheikh - Circulation research, 2015 - Am Heart Assoc
Cardiac muscle cells have an intrinsic ability to sense and respond to mechanical load
through a process known as mechanotransduction. In the heart, this process involves the …
through a process known as mechanotransduction. In the heart, this process involves the …
[HTML][HTML] Central role for GSK3β in the pathogenesis of arrhythmogenic cardiomyopathy
SP Chelko, A Asimaki, P Andersen, D Bedja… - JCI insight, 2016 - ncbi.nlm.nih.gov
Arrhythmogenic cardiomyopathy (ACM) is characterized by redistribution of junctional
proteins, arrhythmias, and progressive myocardial injury. We previously reported that …
proteins, arrhythmias, and progressive myocardial injury. We previously reported that …
Pathophysiology of arrhythmogenic cardiomyopathy
Arrhythmogenic cardiomyopathy (AC) is a clinically and genetically heterogeneous disorder
of heart muscle that is associated with ventricular arrhythmias and risk of sudden cardiac …
of heart muscle that is associated with ventricular arrhythmias and risk of sudden cardiac …
Growth differentiation factor 15 in heart failure: an update
KC Wollert, T Kempf - Current heart failure reports, 2012 - Springer
Abstract Growth differentiation factor 15 (GDF-15) is a stress-responsive cytokine expressed
in the cardiovascular system. GDF-15 is emerging as a biomarker of cardiometabolic risk …
in the cardiovascular system. GDF-15 is emerging as a biomarker of cardiometabolic risk …
Murine electrophysiological models of cardiac arrhythmogenesis
CLH Huang - Physiological reviews, 2017 - journals.physiology.org
Cardiac arrhythmias can follow disruption of the normal cellular electrophysiological
processes underlying excitable activity and their tissue propagation as coherent wavefronts …
processes underlying excitable activity and their tissue propagation as coherent wavefronts …
Aldehyde dehydrogenase 2 ameliorates doxorubicin-induced myocardial dysfunction through detoxification of 4-HNE and suppression of autophagy
Mitochondrial aldehyde dehydrogenase (ALDH2) protects against cardiac injury via
reducing production of 4-hydroxynonenal (4-HNE) and ROS. This study was designed to …
reducing production of 4-hydroxynonenal (4-HNE) and ROS. This study was designed to …
Mud in the blood: the role of protein-mineral complexes and extracellular vesicles in biomineralisation and calcification
W Jahnen-Dechent, A Büscher, S Köppert… - Journal of Structural …, 2020 - Elsevier
Protein-mineral interaction is known to regulate biomineral stability and morphology. We
hypothesise that fluid phases produce highly dynamic protein-mineral complexes involved …
hypothesise that fluid phases produce highly dynamic protein-mineral complexes involved …
[HTML][HTML] Ankyrin-B dysfunction predisposes to arrhythmogenic cardiomyopathy and is amenable to therapy
JD Roberts, NP Murphy, RM Hamilton… - The Journal of …, 2019 - Am Soc Clin Investig
Arrhythmogenic cardiomyopathy (ACM) is an inherited arrhythmia syndrome characterized
by severe structural and electrical cardiac phenotypes, including myocardial fibrofatty …
by severe structural and electrical cardiac phenotypes, including myocardial fibrofatty …
Molecular mechanisms in cardiomyopathy
K Dadson, L Hauck, F Billia - Clinical Science, 2017 - portlandpress.com
Cardiomyopathies represent a heterogeneous group of diseases that negatively affect heart
function. Primary cardiomyopathies specifically target the myocardium, and may arise from …
function. Primary cardiomyopathies specifically target the myocardium, and may arise from …