In the era of evidence-based medicine, the randomized clinical trial corresponds to the top
step in the qualitative scale of the evidence available in the literature, while small series of …

Hyperhomocysteinemia (HHcy) is related to central nervous system diseases.
Epidemiological studies show a positive, dose-dependent relationship between plasma total …

Hyperhomocysteinemia (HHCY) is a risk factor for cardiovascular (CVD) and
neurodegenerative diseases, osteoporotic fractures and pregnancy complications. HHCY is …

Background Elevated plasma homocysteine​​(Hcy) levels have been associated with
cognitive dysfunction in a wide range of conditions. The aim of this review is to establish …

Introduction Although consensus guidelines recommend checking serum B12 in patients
with dementia, clinicians are often faced with various questions:(1) Which patients should be …

Alzheimer's disease, the most common cause of dementia, has a high global economic
impact. To date, there is no curative treatment; therefore, many efforts are directed not only at …

Many lines of independent research have provided convergent evidence regarding
oxidative stress, cerebrovascular disease, dementia, and Alzheimer's disease (AD). Clinical …

Multiple sclerosis (MS) is a complex autoimmune disease that impairs the central nervous
system (CNS). The neurological disability and clinical course of the disease is highly …

A high circulating concentration of the non proteinogenic amino acid homocysteine has
been implicated as a risk factor for Alzheimer's Disease and its prodromal stage, mild …

Abstract Background: B-vitamins (folate, B12) are important micronutrients for brain function
and essential cofactors for homocysteine (HCY) metabolism. Increased HCY has been …