Embryogenic developmental processes involve a tightly controlled regulation between
mechanical forces and biochemical cues such as growth factors, matrix proteins, and …

Among the multiple properties exhibited by lactoferrin (Lf), its involvement in bone
regeneration processes is of great interest at the present time. A series of in vitro and in vivo …

Bone homeostasis is maintained by a balance between osteoblast-mediated bone formation
and osteoclast-driven bone resorption. Hypoxia modulates this relationship partially via …

In the present study, we investigated whether both adipose-derived stem cell (ADSC) and
osteogenic-induced ADSC sheets could promote bone healing in a rat distal femoral …

Introduction Tranexamic acid (TXA) has been shown to be effective at reducing peri-
operative blood loss and haemarthrosis in arthroplasty and arthroscopic soft tissue …

Background Bone erosion is a frequent complication of gout and is strongly associated with
tophi, which are lesions comprising inflammatory cells surrounding collections of …

The development of in vitro models for the maintenance and differentiation of pluripotent
stem cells (PSCs) is an active area of stem cell research. The strategies used so far are …

Lactoferrin is a multifunctional glycoprotein with therapeutic potential for bone tissue
engineering. The aim of this study was to assess the efficacy of local application of …

The scientific community has been doing significant efforts towards engineering new 3D
bone models in recent years. Osteocytes are mechanosensitive cells that play significant …

Although the formation of bone-like nodules is regarded as the differentiation process from
stem cells to osteogenic cells, including osteoblasts and osteocytes, the precise biological …