Macroautophagy/autophagy, is widely recognized for its crucial role in enabling cell survival
and maintaining cellular energy homeostasis during starvation or energy stress. Its …

Cardiac fibrosis is one of the main characteristics of diabetic cardiomyopathy and manifests
excessive accumulation of extracellular matrix proteins in the heart. Several signaling …

Autophagy is a catabolic process whereby cytoplasmic components are degraded within
lysosomes, allowing cells to maintain energy homeostasis during nutrient depletion. Several …

Cardiovascular diseases, the number 1 cause of death worldwide, are frequently associated
with apoptotic death of cardiac myocytes. Since cardiomyocyte apoptosis is a highly …

MicroRNAs have emerged as crucial regulators of cardiac homeostasis and remodeling in
various cardiovascular diseases. We previously demonstrated that miR-221 regulated …

Evidence is accumulating that the main chronic diseases of aging Alzheimer's disease (AD)
and type-2 diabetes mellitus (T2DM) share common pathophysiological mechanisms. This …

Skeletal muscle stem cell (MuSC) function declines with age and contributes to impaired
muscle regeneration in older individuals. Acting through AMPK/p27 Kip1, we have identified …

Initially described as lytic bodies due to their degradative and recycling functions, lysosomes
play a critical role in metabolic adaptation to nutrient availability. More recently, the …

Background. Exercise benefits to cardiac rehabilitation (CR) following stable myocardial
infarction (MI). The suitable exercise duration for aged patients with coronary heart disease …

Once believed to solely function as a cyclin-dependent kinase inhibitor, p27Kip1 is now
emerging as a critical mediator of autophagy, cytoskeletal dynamics, cell migration and …