Fast-acting chemical tools to delineate causality in transcriptional control
Multi-dimensional omics profiling continues to illuminate the complexity of cellular
processes. Because of difficult mechanistic interpretation of phenotypes induced by slow …
processes. Because of difficult mechanistic interpretation of phenotypes induced by slow …
From telomere to telomere: The transcriptional and epigenetic state of human repeat elements
Mobile elements and repetitive genomic regions are sources of lineage-specific genomic
innovation and uniquely fingerprint individual genomes. Comprehensive analyses of such …
innovation and uniquely fingerprint individual genomes. Comprehensive analyses of such …
UTX condensation underlies its tumour-suppressive activity
UTX (also known as KDM6A) encodes a histone H3K27 demethylase and is an important
tumour suppressor that is frequently mutated in human cancers. However, as the …
tumour suppressor that is frequently mutated in human cancers. However, as the …
R-loop-dependent promoter-proximal termination ensures genome stability
C Xu, C Li, J Chen, Y Xiong, Z Qiao, P Fan, C Li, S Ma… - Nature, 2023 - nature.com
The proper regulation of transcription is essential for maintaining genome integrity and
executing other downstream cellular functions,. Here we identify a stable association …
executing other downstream cellular functions,. Here we identify a stable association …
FLEP-seq: simultaneous detection of RNA polymerase II position, splicing status, polyadenylation site and poly (A) tail length at genome-wide scale by single …
Elongation, splicing and polyadenylation are fundamental steps of transcription, and
studying their coordination requires simultaneous monitoring of these dynamic processes on …
studying their coordination requires simultaneous monitoring of these dynamic processes on …
Ligand-induced native G-quadruplex stabilization impairs transcription initiation
C Li, H Wang, Z Yin, P Fang, R Xiao, Y Xiang… - Genome …, 2021 - genome.cshlp.org
G-quadruplexes (G4s) are noncanonical DNA secondary structures formed through the self-
association of guanines, and G4s are distributed widely across the genome. G4 participates …
association of guanines, and G4s are distributed widely across the genome. G4 participates …
Recurrent evolution of vertebrate transcription factors by transposase capture
RL Cosby, J Judd, R Zhang, A Zhong, N Garry… - Science, 2021 - science.org
INTRODUCTION How novel protein architectures evolve remains poorly understood. The
rearrangement of domains with preexisting functions into new composite architectures …
rearrangement of domains with preexisting functions into new composite architectures …
SPT6 functions in transcriptional pause/release via PAF1C recruitment
Y Aoi, AP Shah, S Ganesan, SHA Soliman, BK Cho… - Molecular cell, 2022 - cell.com
It is unclear how various factors functioning in the transcriptional elongation by RNA
polymerase II (RNA Pol II) cooperatively regulate pause/release and productive elongation …
polymerase II (RNA Pol II) cooperatively regulate pause/release and productive elongation …
SPT5 stabilizes RNA polymerase II, orchestrates transcription cycles, and maintains the enhancer landscape
Transcription progression is governed by multitasking regulators including SPT5, an
evolutionarily conserved factor implicated in virtually all transcriptional steps from enhancer …
evolutionarily conserved factor implicated in virtually all transcriptional steps from enhancer …
SPT5 stabilization of promoter-proximal RNA polymerase II
Y Aoi, YH Takahashi, AP Shah, M Iwanaszko… - Molecular cell, 2021 - cell.com
Based on in vitro studies, it has been demonstrated that the DSIF complex, composed of
SPT4 and SPT5, regulates the elongation stage of transcription catalyzed by RNA …
SPT4 and SPT5, regulates the elongation stage of transcription catalyzed by RNA …