ABSTRACT The Cre/Lox system is a powerful tool in the biologist's toolbox, allowing loss‐of‐
function and gain‐of‐function studies, as well as lineage tracing, through gene …

Low back pain (LBP) is quite common in clinical practice, which can lead to long-term bed
rest or even disability. It is a worldwide health problem remains to be solved. LBP can be …

Intervertebral disc degeneration (IDD) has been generally accepted as the major cause of
low back pain (LBP), which causes an enormous socioeconomic burden. Previous studies …

Intervertebral disc degeneration (IDD) is the pathological reason of back pain and the
therapeutic approaches are still unsatisfactory. Recently, mesenchymal stem cell-derived …

Intervertebral disc (IVD) degeneration is the major contributor to low back pain, a highly
prevalent musculoskeletal problem that represents the leading cause of disability …

Intervertebral disc degeneration (IDD) is a major cause of lower back pain, but the specific
molecular mechanisms governing its development are poorly characterized. This study …

Disruption of the intervertebral disc extracellular matrix (ECM) is a hallmark of intervertebral
disc degeneration (IDD), which is largely attributed to excessive oxidative stress. However …

Osteoblasts, the chief bone‐forming cells, are differentiated from mesenchymal stromal/stem
cells. Disruption of this differentiation process can cause osteoporosis, a bone disease …

Cre/loxP technology is an important tool for studying cell type‐specific gene functions. Cre
recombinase mouse lines, including Agc1‐CreERT2, Col2a1‐Cre; Col2a1‐CreERT2, Shh …

Intervertebral disc (IVD) degeneration (IDD) is the most universal pathogenesis of low back
pain (LBP), a prevalent and costly medical problem across the world. Persistent low back …