Is IgE or eosinophils the key player in allergic asthma pathogenesis? Are we asking the right question?
A Matucci, A Vultaggio, E Maggi, I Kasujee - Respiratory research, 2018 - Springer
Bronchial asthma (BA) is a chronic inflammatory disease with a marked heterogeneity in
pathophysiology and etiology. The heterogeneity of BA may be related to the inducing …
pathophysiology and etiology. The heterogeneity of BA may be related to the inducing …
Functional role of probiotics and prebiotics on skin health and disease
V Lolou, MI Panayiotidis - Fermentation, 2019 - mdpi.com
Scientific and commercial interest of probiotics, prebiotics and their effect on human health
and disease has increased in the last decade. The aim of this review article is to evaluate …
and disease has increased in the last decade. The aim of this review article is to evaluate …
Treatment of allergic asthma: modulation of Th2 cells and their responses
B Bosnjak, B Stelzmueller, KJ Erb, MM Epstein - Respiratory research, 2011 - Springer
Atopic asthma is a chronic inflammatory pulmonary disease characterised by recurrent
episodes of wheezy, laboured breathing with an underlying Th2 cell-mediated inflammatory …
episodes of wheezy, laboured breathing with an underlying Th2 cell-mediated inflammatory …
Pathogenic CD4+ T cells in patients with asthma
Asthma encompasses a variety of clinical phenotypes that involve distinct T cell–driven
inflammatory processes. Improved understanding of human T-cell biology and the influence …
inflammatory processes. Improved understanding of human T-cell biology and the influence …
Allergens and their role in the allergic immune response
TAE Platts‐Mills, JA Woodfolk - Immunological reviews, 2011 - Wiley Online Library
Allergens are recognized as the proteins that induce immunoglobulin E (IgE) responses in
humans. The proteins come from a range of sources and, not surprisingly, have many …
humans. The proteins come from a range of sources and, not surprisingly, have many …
Current understanding of the immunomodulatory activities of high-density lipoproteins
A Trakaki, G Marsche - Biomedicines, 2021 - mdpi.com
Lipoproteins interact with immune cells, macrophages and endothelial cells-key players of
the innate and adaptive immune system. High-density lipoprotein (HDL) particles seem to …
the innate and adaptive immune system. High-density lipoprotein (HDL) particles seem to …
Repertoire-scale determination of class II MHC peptide binding via yeast display improves antigen prediction
CD4+ helper T cells contribute important functions to the immune response during pathogen
infection and tumor formation by recognizing antigenic peptides presented by class II major …
infection and tumor formation by recognizing antigenic peptides presented by class II major …
T helper 17 cells may drive neuroprogression in major depressive disorder: proposal of an integrative model
The exact pathophysiology of major depressive disorder (MDD) remains elusive. The
monoamine theory, which hypothesizes that MDD emerges as a result of dysfunctional …
monoamine theory, which hypothesizes that MDD emerges as a result of dysfunctional …
Filaggrin inhibits generation of CD1a neolipid antigens by house dust mite–derived phospholipase
R Jarrett, M Salio, A Lloyd-Lavery… - Science translational …, 2016 - science.org
Atopic dermatitis is a common pruritic skin disease in which barrier dysfunction and
cutaneous inflammation contribute to pathogenesis. Mechanisms underlying the associated …
cutaneous inflammation contribute to pathogenesis. Mechanisms underlying the associated …
Eosinophilic gastrointestinal disease and peanut allergy are alternatively associated with IL-5+ and IL-5− TH2 responses
C Prussin, J Lee, B Foster - Journal of allergy and clinical immunology, 2009 - Elsevier
BACKGROUND: Both anaphylactic food allergy and eosinophil-associated gastrointestinal
disorders are associated with TH2 responses and food-specific IgE, yet they have very …
disorders are associated with TH2 responses and food-specific IgE, yet they have very …