Dihydroartemisinin (DHA) is an active metabolite of artemisinin and its derivatives (ARTs),
and it is an effective clinical drug widely used to treat malaria. Recently, the anticancer …

The side-effects and long-term sequelae of anti-cancer chemotherapy remain a major
source of concern for both patients and clinicians despite the improved efficacy and …

Background National levels of personal health-care access and quality can be
approximated by measuring mortality rates from causes that should not be fatal in the …

Updating of systematic reviews is generally more efficient than starting all over again when
new evidence emerges, but to date there has been no clear guidance on how to do this. This …

Recent gains in the fight against malaria are threatened by the emergence and spread of
artemisinin and partner drug resistance in Plasmodium falciparum in the Greater Mekong …

Malaria remains a major cause of morbidity and mortality in the tropics, with Plasmodium
falciparum responsible for the majority of the disease burden and P. vivax being the …

Screening of small-molecule libraries is a productive method for identifying both chemical
probes of disease-related targets and potential starting points for drug discovery. In this …

Artemisinins are the most rapidly acting of currently available antimalarial drugs. Artesunate
has become the treatment of choice for severe malaria, and artemisinin-based combination …

Artemisinin combination therapies are the first-line treatments for uncomplicated
Plasmodium falciparum malaria in most malaria-endemic countries. Recently, partial …

Artemisinin and its derivatives have become essential components of antimalarial treatment.
These plant-derived peroxides are unique among antimalarial drugs in killing the young …