The forebrain is the seat of higher-order brain functions, and many human neuropsychiatric
disorders are due to genetic defects affecting forebrain development, making it imperative to …

The mammalian neocortex gives rise to a wide range of mental activities and consists of a
constellation of interconnected areas that are built from a set of basic circuit templates. Major …

The human brain undergoes rapid development at mid-gestation from a pool of neural stem
and progenitor cells (NSPCs) that give rise to the neurons, oligodendrocytes, and astrocytes …

Cortical interneurons (INs) are a diverse group of neurons that project locally and shape the
function of neural networks throughout the brain. Multiple lines of evidence suggest that a …

Elucidating the transcriptional circuitry controlling forebrain development requires an
understanding of enhancer activity and regulation. We generated stable transgenic mouse …

The Otx2 homeodomain transcription factor is essential for gastrulation and early neural
development. We generated Otx2 conditional knockout (cKO) mice to investigate its roles in …

Enhancers integrate transcription factor signaling pathways that drive cell fate specification
in the developing brain. We paired enhancer labeling and single-cell RNA-sequencing …

Background Binge alcohol exposure during adolescence results in long‐lasting alterations
in the brain and behavior. For example, adolescent intermittent ethanol (AIE) exposure in …

Previous research has linked the contribution of interneuronal networks in the primary motor
cortex (M1) to motor planning, preparation and execution. The non-invasive recruitment of …

A recent large genome-wide association study identifiedMIR137 as a leading candidate
gene for schizophrenia. The promoter SNP rs2660304 may contribute to schizophrenia …