Bench to bedside—new insights into the pathogenesis of necrotizing enterocolitis
Necrotizing enterocolitis (NEC) is the leading cause of death and disability from
gastrointestinal disease in premature infants. Recent discoveries have shed light on a …
gastrointestinal disease in premature infants. Recent discoveries have shed light on a …
Toll-like receptors: significance, ligands, signaling pathways, and functions in mammals
This review attempts to cover the implication of the toll-like receptors (TLRs) in controlling
immune functions with emphasis on their significance, function, regulation and expression …
immune functions with emphasis on their significance, function, regulation and expression …
Maternal microbiota, early life colonization and breast milk drive immune development in the newborn
C Kalbermatter, N Fernandez Trigo… - Frontiers in …, 2021 - frontiersin.org
The innate immune system is the oldest protection strategy that is conserved across all
organisms. Although having an unspecific action, it is the first and fastest defense …
organisms. Although having an unspecific action, it is the first and fastest defense …
Necrotizing enterocolitis: new insights into pathogenesis and mechanisms
Necrotizing enterocolitis (NEC) is the most frequent and lethal disease of the gastrointestinal
tract of preterm infants. At present, NEC is thought to develop in the premature host in the …
tract of preterm infants. At present, NEC is thought to develop in the premature host in the …
Potential role of gut microbiota in induction and regulation of innate immune memory
The gut microbiota significantly regulates the development and function of the innate and
adaptive immune system. The attribute of immunological memory has long been linked only …
adaptive immune system. The attribute of immunological memory has long been linked only …
[HTML][HTML] Neonatal gut microbiome and immunity
KZ Sanidad, MY Zeng - Current opinion in microbiology, 2020 - Elsevier
Highlights•In utero microbial stimulation modulates both prenatal and postnatal immune cell
development.•Unique neonatal gut microenvironment allows for progressive colonization of …
development.•Unique neonatal gut microenvironment allows for progressive colonization of …
Necrotizing enterocolitis: It's not all in the gut
AL Meister, KK Doheny… - Experimental biology and …, 2020 - journals.sagepub.com
Necrotizing enterocolitis is the leading cause of death due to gastrointestinal disease in
preterm neonates, affecting 5–12% of neonates born at a very-low birth weight. Necrotizing …
preterm neonates, affecting 5–12% of neonates born at a very-low birth weight. Necrotizing …
Toll-like receptor signalling in the intestinal epithelium: how bacterial recognition shapes intestinal function
MT Abreu - Nature reviews immunology, 2010 - nature.com
A single layer of epithelial cells lines the small and large intestines and functions as a barrier
between commensal bacteria and the rest of the body. Ligation of Toll-like receptors (TLRs) …
between commensal bacteria and the rest of the body. Ligation of Toll-like receptors (TLRs) …
The human milk oligosaccharides 2'-fucosyllactose and 6'-sialyllactose protect against the development of necrotizing enterocolitis by inhibiting toll-like receptor 4 …
Background Necrotizing enterocolitis (NEC) develops through exaggerated toll-like receptor
4 (TLR4) signaling in the intestinal epithelium. Breast milk is rich in non-digestible …
4 (TLR4) signaling in the intestinal epithelium. Breast milk is rich in non-digestible …
Necrotizing enterocolitis
J Duchon, ME Barbian… - Clinics in …, 2021 - perinatology.theclinics.com
Necrotizing enterocolitis (NEC) is a devastating intestinal disorder characterized by
intestinal inflammation and necrosis. 1 This disease is one of the most common …
intestinal inflammation and necrosis. 1 This disease is one of the most common …