At the turn of the century, researchers discovered a unique subtype of T helper cells that
secretes IL-17 and defined it as Th17. The latest study found that Th17 cells play both …

Recently, increased interest in the use of Tregs as adoptive cell therapy for the treatment of
autoimmune diseases and transplant rejection had led to several advances in the field …

Background Multiple genetic modifications may be required to develop potent off-the-shelf
chimeric antigen receptor (CAR) T cell therapies. Conventional CRISPR-Cas nucleases …

As the body's integumentary system, the skin is vulnerable to injuries. The subsequent
wound healing processes aim to restore dermal and epidermal integrity and functionality. To …

Engineered T cells represent an emerging therapeutic modality. However, complex
engineering strategies can present a challenge for enriching and expanding therapeutic …

Rejection of solid organ transplant and graft versus host disease (GvHD) continue to be
challenging in post transplantation management. The introduction of calcineurin inhibitors …

The importance of regulatory T cells (Tregs) in preventing autoimmunity has been well
established; however, the precise alterations in Treg function in autoimmune individuals and …

Despite an ever-increasing appreciation of how protein-coding genes shape immune
responses, the molecular underpinnings of immune regulation remain incompletely …

Graft-versus-host disease (GVHD) is the leading cause of morbidity and mortality after
allogeneic hematopoietic stem cell transplantation (allo-HSCT). Immunomodulation using …

Ethnopharmacological relevance Atopic dermatitis (AD) is a prevalent chronic inflammatory
skin disorder that poses a significant global health challenge. There is a lack of safe and …