Pim oncogenes are overexpressed in a wide range of tumours from a haematological and
epithelial origin. Pim genes encode serine/threonine kinases that have been shown to …

Activation of transcription factor NF-κB is frequently encountered in tumor cells and
contributes to aggressive tumor growth and resistance to chemotherapy and ionizing …

Docetaxel is a standard chemotherapy for patients with metastatic prostate cancer. However,
the response is rather limited and not all of the patients benefit from this treatment. To …

The proviral insertion site in Moloney murine leukemia virus, or PIM proteins, are a family of
serine/threonine kinases composed of three different isoforms (PIM1, PIM2, and PIM3) that …

Evidence suggests that multiple tumors, including pancreatic adenocarcinoma, display
heterogeneity in parameters that are critical for tumor formation, progression and metastasis …

BACKGROUND Bee venom has been used as a traditional medicine to treat arthritis,
rheumatism, back pain, cancerous tumors, and skin diseases. However, the effects of bee …

Several mechanisms facilitate the progression of hormone-sensitive prostate cancer to
castration-resistant prostate cancer (CRPC). At present, the approved chemotherapies for …

Over the past 5 years, the advent of combination therapeutic strategies has substantially
reshaped the clinical management of patients with advanced prostate cancer. However …

Background—Pulmonary artery hypertension (PAH) is a proliferative disorder associated
with enhanced pulmonary artery smooth muscle cell proliferation and suppressed apoptosis …

Idiopathic pulmonary fibrosis (IPF) is an aging-associated disease characterized by
myofibroblast accumulation and progressive lung scarring. To identify transcriptional gene …