Abstract Alzheimer's disease (AD), similar to AD-related dementias, is characterized by
impaired/lost neuronal structures and functions due to a long progression of …

Estrogens have inconsistent effects on learning and memory in both the clinical and
preclinical literature. Preclinical literature has the advantage of investigating an array of …

Abstract 17β-estradiol, the most biologically active estrogen, exerts wide-ranging effects in
brain through its action on estrogen receptors (ERs), influencing higher-order cognitive …

Global prevalence of Alzheimer's Disease has a strong sex bias, with women representing
approximately two‐thirds of the patients. Yet, the role of sex‐specific risk factors during …

Introduction Despite evidence from preclinical studies suggesting estrogen's neuroprotective
effects, the use of menopausal hormone therapy (MHT) to support cognitive function remains …

Estrogens are pivotal regulators of brain function throughout the lifespan, exerting profound
effects from early embryonic development to aging. Extensive experimental evidence …

Increasing evidence suggests that female individuals have a higher Alzheimer's disease
(AD) risk associated with post-menopausal loss of circulating estradiol (E2). However …

Abstract Changes in the transition metal homeostasis in the brain are closely linked with
Alzheimer's disease (AD), including intraneuronal iron accumulation and extracellular …

Pregnancy and motherhood can have long-term effects on cognition and brain aging in both
humans and rodents. Estrogens are related to cognitive function and neuroplasticity …

In recent years, a burgeoning field of research has focused on women's mental health and
psychiatric conditions associated with perinatal and postpartum periods. An emerging trend …