[HTML][HTML] ABC transporters affects tumor immune microenvironment to regulate cancer immunotherapy and multidrug resistance
Multidrug resistance (MDR) is the phenomenon in which cancer cells simultaneously
develop resistance to a broad spectrum of structurally and mechanistically unrelated drugs …
develop resistance to a broad spectrum of structurally and mechanistically unrelated drugs …
PomBase: a Global Core Biodata Resource—growth, collaboration, and sustainability
KM Rutherford, M Lera-Ramírez, V Wood - Genetics, 2024 - academic.oup.com
Abstract PomBase (https://www. pombase. org), the model organism database (MOD) for
fission yeast, was recently awarded Global Core Biodata Resource (GCBR) status by the …
fission yeast, was recently awarded Global Core Biodata Resource (GCBR) status by the …
COSMIC: a curated database of somatic variants and clinical data for cancer
Z Sondka, NB Dhir, D Carvalho-Silva… - Nucleic Acids …, 2024 - academic.oup.com
Abstract The Catalogue Of Somatic Mutations In Cancer (COSMIC), https://cancer. sanger.
ac. uk/cosmic, is an expert-curated knowledgebase providing data on somatic variants in …
ac. uk/cosmic, is an expert-curated knowledgebase providing data on somatic variants in …
Spatially resolved multiomics of human cardiac niches
The function of a cell is defined by its intrinsic characteristics and its niche: the tissue
microenvironment in which it dwells. Here we combine single-cell and spatial …
microenvironment in which it dwells. Here we combine single-cell and spatial …
The IUPHAR/BPS guide to PHARMACOLOGY in 2024
SD Harding, JF Armstrong, E Faccenda… - Nucleic acids …, 2024 - academic.oup.com
Abstract The IUPHAR/BPS Guide to PHARMACOLOGY (GtoPdb; https://www.
guidetopharmacology. org) is an open-access, expert-curated, online database that …
guidetopharmacology. org) is an open-access, expert-curated, online database that …
Large-scale foundation model on single-cell transcriptomics
Large pretrained models have become foundation models leading to breakthroughs in
natural language processing and related fields. Developing foundation models for …
natural language processing and related fields. Developing foundation models for …
LncRNA NNT-AS1/hsa-miR-485–5p/HSP90 axis in-silico and clinical prospect correlated-to histologic grades-based CRC stratification: A step toward ncRNA …
NM El-Sheikh, AI Abulsoud, A Fawzy, EF Wasfey… - … -Research and Practice, 2023 - Elsevier
The oncogenic effects of long non-coding RNA (lncRNA) Nicotinamide Nucleotide
Transhydrogenase-antisense RNA1 (NNT-AS1) role in colorectal cancer (CRC) hasn't been …
Transhydrogenase-antisense RNA1 (NNT-AS1) role in colorectal cancer (CRC) hasn't been …
VARIDT 3.0: the phenotypic and regulatory variability of drug transporter
The phenotypic and regulatory variability of drug transporter (DT) are vital for the
understanding of drug responses, drug-drug interactions, multidrug resistances, and so on …
understanding of drug responses, drug-drug interactions, multidrug resistances, and so on …
The Monarch Initiative in 2024: an analytic platform integrating phenotypes, genes and diseases across species
TE Putman, K Schaper, N Matentzoglu… - Nucleic acids …, 2024 - academic.oup.com
Bridging the gap between genetic variations, environmental determinants, and phenotypic
outcomes is critical for supporting clinical diagnosis and understanding mechanisms of …
outcomes is critical for supporting clinical diagnosis and understanding mechanisms of …
Evaluation of large language models for discovery of gene set function
Gene set enrichment is a mainstay of functional genomics, but it relies on gene function
databases that are incomplete. Here we evaluate five large language models (LLMs) for …
databases that are incomplete. Here we evaluate five large language models (LLMs) for …