G protein-gated inwardly rectifying potassium channels (Kir3/GirK) are important for
maintaining resting membrane potential, cell excitability and inhibitory neurotransmission …

Parkinson's disease (PD) is a neurodegenerative disorder characterized by selective loss of
dopaminergic neurons in the substantia nigra pars compacta (SNpc) region of the midbrain …

A long-standing goal in protein science and clinical genetics is to develop quantitative
models of sequence, structure, and function relationships to understand how mutations …

For the past two decades several scholarly reviews have appeared on the inwardly rectifying
potassium (Kir) channels. We would like to highlight two efforts in particular, which have …

Adaptive plasticity processes are required involving neurons as well as non-neuronal cells
to recover lost brain functions after an ischemic stroke. Recent studies show that gamma …

G-protein–gated inwardly-rectifying K+(GIRK) channels are targets of G i/o-protein–signaling
systems that inhibit cell excitability. GIRK channels exist as homotetramers (GIRK2 and …

Locomotor sensitization (LS) is an early behavioral adaptation to addictive drugs, driven by
the increase of dopamine in the Nucleus Accumbens (NAc). However, the effect on …

Dopamine (DA) neurons of the VTA have been widely implicated in the cellular and
behavioral responses to drugs of abuse. Inhibitory G protein signaling mediated by GABAB …

G protein-gated inwardly rectifying potassium (GIRK) channels are important inhibitory
regulators of neuronal excitability in central nervous system, and the impairment of GIRK …

Besides their primary function mediating the repolarization phase of action potentials,
potassium channels exquisitely and ubiquitously regulate the resting membrane potential of …