The Wnt pathway is central to a host of developmental and disease-related processes. The
remarkable conservation of this intercellular signaling cascade throughout metazoan …

Since the recognition that mutations in components of the Wnt–β-catenin pathway underlie
some human cancers, considerable attention has been dedicated to developing therapeutic …

The conclusive identity of Wnts regulating liver zonation (LZ) and regeneration (LR) remains
unclear despite an undisputed role of β-catenin. Using single-cell analysis, we identified a …

Summary Wnt ligands oligomerize Frizzled (Fzd) and Lrp5/6 receptors to control the
specification and activity of stem cells in many species. How Wnt signaling is selectively …

Derangements of the blood-brain barrier (BBB) or blood-retinal barrier (BRB) occur in
disorders ranging from stroke, cancer, diabetic retinopathy, and Alzheimer's disease. The …

Inherited retinal dystrophies (IRDs) are congenital retinal degenerative diseases that have
various inheritance patterns, including dominant, recessive, X-linked, and mitochondrial …

Proper functioning of the neural retina relies on the unique retinal environment regulated by
the blood–retinal barrier (BRB), which restricts the passage of solutes, fluids, and toxic …

Wnt signaling comprises a group of complex signal transduction pathways that play critical
roles in cell proliferation, differentiation, and apoptosis during development, as well as in …

Background Wnt/β-catenin signaling is critical for lung development and AT2 stem cell
maintenance in adults, but excessive pathway activation has been associated with …

During embryo development, cell proliferation, cell fate specification and tissue patterning
are coordinated and tightly regulated by a handful of evolutionarily conserved signaling …