Evolving therapeutic landscape of advanced hepatocellular carcinoma

C Yang, H Zhang, L Zhang, AX Zhu… - Nature reviews …, 2023 - nature.com
Hepatocellular carcinoma (HCC) is one of the most common solid malignancies worldwide.
A large proportion of patients with HCC are diagnosed at advanced stages and are only …

Global epidemiology and genetics of hepatocellular carcinoma

MR Toh, EYT Wong, SH Wong, AWT Ng, LH Loo… - Gastroenterology, 2023 - Elsevier
Hepatocellular carcinoma (HCC) is one of the leading cancers worldwide. Classically, HCC
develops in genetically susceptible individuals who are exposed to risk factors, especially in …

Role of gut microbiome in cancer immunotherapy: from predictive biomarker to therapeutic target

M Zhang, J Liu, Q Xia - Experimental Hematology & Oncology, 2023 - Springer
Immunotherapy has emerged as an effective treatment for various types of cancers. Recent
studies have highlighted a significant correlation between the gut microbiome and patients' …

Functional and therapeutic significance of tumor-associated macrophages in colorectal cancer

Y Li, Z Chen, J Han, X Ma, X Zheng, J Chen - Frontiers in Oncology, 2022 - frontiersin.org
The role of the tumor microenvironment (TME) in the progression of colorectal cancer (CRC)
and its acquisition of resistance to treatment become the research hotspots. As an important …

Role of intestinal microbes in chronic liver diseases

M Xu, K Luo, J Li, Y Li, Y Zhang, Z Yuan, Q Xu… - International Journal of …, 2022 - mdpi.com
With the recent availability and upgrading of many emerging intestinal microbes sequencing
technologies, our research on intestinal microbes is changing rapidly. A variety of …

Potential predictive role of gut microbiota to immunotherapy in HCC patients: a brief review

P Muscolino, B Granata, F Omero… - Frontiers in …, 2023 - frontiersin.org
The recent evolution of immunotherapy has revolutionised the treatment of hepatocellular
carcinoma (HCC) and has led to new therapeutic standards. The advances in …

An immunological perspective on the mechanism of drug induced liver injury: focused on drugs for treatment of hepatocellular carcinoma and liver transplantation

SK Lee, JY Choi, ES Jung, JH Kwon, JW Jang… - International Journal of …, 2023 - mdpi.com
The liver is frequently exposed to potentially toxic materials, and it is the primary site of
clearance of foreign agents, along with many innate and adaptive immune cells …

Dysbiosis of the gut microbiome in elderly patients with hepatocellular carcinoma

W Zhang, X Xu, L Cai, X Cai - Scientific Reports, 2023 - nature.com
Fecal samples from participants aged 60–80 were collected and sequenced by a high-
throughput second-generation sequencer to explore the structural composition of gut …

[HTML][HTML] Gut microbiota modulation: a viable strategy to address medical needs in hepatocellular carcinoma and liver transplantation

Z Xiang, J Wu, J Li, S Zheng, X Wei, X Xu - Engineering, 2023 - Elsevier
Hepatocellular carcinoma (HCC) is the most common malignancy of the liver, posing a
significant threat to public health. Although liver transplantation (LT) is an effective treatment …

Long non-coding RNAs (lncRNAs) in hepatocellular carcinoma progression: Biological functions and new therapeutic targets

M Hashemi, S Mirzaei, MA Zandieh, S Rezaei… - Progress in biophysics …, 2023 - Elsevier
Liver is an important organ in body that performs vital functions such as detoxification. Liver
is susceptible to development of cancers, and hepatocellular carcinoma (HCC) is among …