Alpha-2-macroglobulin is an extracellular macromolecule mainly known for its role as a
broad-spectrum protease inhibitor. By presenting itself as an optimal substrate for …

An excessive immune response contributes to SARS-CoV, MERS-CoV and SARS-CoV-2
pathogenesis and lethality, but the mechanism remains unclear. In this study, the N proteins …

Excessive inflammatory responses contribute to the pathogenesis and lethality of highly
pathogenic human coronaviruses, but the underlying mechanism remains unclear. In this …

Summary Mannose‐binding lectin (MBL), collectin‐10, collectin‐11, and the ficolins (ficolin‐
1, ficolin‐2, and ficolin‐3) are soluble pattern recognition molecules in the lectin complement …

Introduction: The complement system is essential for an adequate immune response. Much
attention has been given to the role of complement in disease. However, to better …

IgA nephropathy (IgAN) is characterized by glomerular co-deposition of IgA and complement
components. Earlier studies showed that IgA activates the alternative pathway of …

The complement system is pivotal in host defense but also contributes to tissue injury in
several diseases. The assembly of C3 convertases (C4b2a and C3bBb) is a prerequisite for …

The lectin pathway of complement activation is an important component of the innate
immune defense. The initiation complexes of the lectin pathway consist of a recognition …

The complement system is an important immune mechanism mediating both recognition and
elimination of foreign bodies. The lectin pathway is one pathway of three by which the …

Mannan-binding lectin (MBL), L-ficolin, M-ficolin and H-ficolin are all complement activating
soluble pattern recognition molecules with recognition domains linked to collagen-like …