Although anxiety disorders represent a major societal problem demanding new therapeutic
targets, these efforts have languished in the absence of a mechanistic understanding of this …

Surviving threats in the environment requires brain circuits for detecting (or anticipating)
danger and for coordinating appropriate defensive responses (eg, increased cardiac output …

Triggering behavioral adaptation upon the detection of adversity is crucial for survival. The
insular cortex has been suggested to process emotions and homeostatic signals, but how …

The co-morbidity of anxiety and dysfunctional reward processing in illnesses such as
addiction and depression suggests that common neural circuitry contributes to these …

Social animals detect the affective states of conspecifics and utilize this information to
orchestrate social interactions. In a social affective preference text in which experimental …

Heightened fear and inefficient safety learning are key features of fear and anxiety disorders.
Evidence-based interventions for anxiety disorders, such as cognitive behavioral therapy …

Entering a state of anxious anticipation triggers widespread changes across large-scale
networks in the brain. The temporal aspects of this transition into an anxious state are poorly …

The bed nucleus of the stria terminalis (BNST) has been implicated in conditioned fear and
anxiety, but the specific factors that engage the BNST in defensive behaviors are unclear …

Safety signals are learned cues that predict the nonoccurrence of an aversive event. As
such, safety signals are potent inhibitors of fear and stress responses. Investigations of …

Safety learning occurs when an otherwise neutral stimulus comes to signal the absence of
threat, allowing organisms to use safety information to inhibit fear and anxiety in …