The genetics of atypical femur fractures—a systematic review

W Zhou, JGJ van Rooij, PR Ebeling… - Current osteoporosis …, 2021 - Springer
Abstract Purpose of Review Atypical femur fractures (AFFs) are rare subtrochanteric or
diaphyseal fractures regarded as side effects of bisphosphonates (BPs), possibly with a …

Management of endocrine disease: atypical femoral fractures: risks and benefits of long-term treatment of osteoporosis with anti-resorptive therapy

RA Adler - European Journal of Endocrinology, 2018 - academic.oup.com
Modern osteoporosis treatment began in the mid-1990s with the approval of amino-
bisphosphonates, anti-resorptive agents that have been shown to decrease osteoporotic …

[HTML][HTML] Biological activity is not suppressed in mid-shaft stress fracture of the bowed femoral shaft unlike in “typical” atypical subtrochanteric femoral fracture: a …

Y Oh, K Yamamoto, J Hashimoto, K Fujita, T Yoshii… - Bone, 2020 - Elsevier
Background We have investigated mid-shaft stress fractures of the bowed femoral shaft
(SBFs), well before the first report of an association between suppression of bone turnover …

Influence of geometry on proximal femoral shaft strains: implications for atypical femoral fracture

IT Haider, P Schneider, A Michalski, WB Edwards - Bone, 2018 - Elsevier
Introduction Atypical femoral fractures (AFF) are characterized as low-energy fractures of the
femoral shaft or subtrochanteric region. Femoral geometry is known to play a role in AFF …

Biomechanical mechanisms of atypical femoral fracture

A Ural - Journal of the mechanical behavior of biomedical …, 2021 - Elsevier
Antiresorptives such as bisphosphonates (BP) and denosumab are commonly used
osteoporosis treatments that are effective in preventing osteoporotic fractures by …

How Advancement in Bone Science Should Inform the Examination and Treatment of Femoral Shaft Bone Stress Injuries in Running Athletes

EJ Hegedus, EP Mulligan, BA Beer, AS Gisselman… - Sports Medicine, 2023 - Springer
Stress fractures likely have a 1–2% incidence in athletes in general. In runners, a more
vulnerable population, incidence rates likely range between 3.2 and 21% with female …

The role of lower-limb geometry in the pathophysiology of atypical femoral fracture

IT Haider, PS Schneider, WB Edwards - Current osteoporosis reports, 2019 - Springer
Abstract Purposeof Review The etiology of atypical femoral fracture (AFF) is likely
multifactorial. In this review, we examined the recent literature investigating the role of lower …

Potential bone fragility of mid-shaft atypical femoral fracture: biomechanical analysis by a CT-based nonlinear finite element method

A Tano, Y Oh, K Fukushima, Y Kurosa, Y Wakabayashi… - Injury, 2019 - Elsevier
Introduction The authors previously reported a CT-based nonlinear finite element analysis
(nonlinear CT/FEA) model to investigate loading stress distribution in the femoral shaft of …

Update on rare adverse events from osteoporosis therapy and bisphosphonate drug holidays

RA Adler - Endocrinology and Metabolism Clinics, 2021 - endo.theclinics.com
Osteoporosis remains an important but underappreciated disorder. In the United States,
there are at least 2 million osteoporotic fractures every year. Vertebral fractures are the most …

Differences in femur geometry and bone markers in atypical femur fractures and the general population

IJ Jung, JW Kim - Scientific Reports, 2021 - nature.com
This study aimed to identify differences in femur geometry between patients with
subtrochanteric/shaft atypical femur fractures (AFFs) and the general population, and to …