Cerebral small vessel disease (CSVD) represents a diverse cluster of cerebrovascular
diseases primarily affecting small arteries, capillaries, arterioles and venules. The diagnosis …

Background Cell-based strategies focusing on replacement or protection of dopaminergic
neurons have been considered as a potential approach to treat Parkinson's disease (PD) for …

Stem cell therapy is an emerging treatment paradigm for stroke patients with remaining
neurological deficits. While allogeneic cell transplants overcome the manufacturing …

Neuroinflammation is a significant and modifiable cause of secondary injury after traumatic
brain injury (TBI), driven by both central and peripheral immune responses. A substantial …

The global trend toward aging populations has resulted in an increase in the occurrence of
Alzheimer's disease (AD) and associated socioeconomic burdens. Abnormal metabolism of …

Unraveling the pathology of stroke is a prerequisite for designing therapeutic strategies. It
was reported that myelin injury exceeded axonal loss in the peri-infarct region of rodent …

Oligodendrocytes are main targets in demyelinating and dysmyelinating diseases of the
central nervous system (CNS), but are also involved in accidental, neurodegenerative and …

Background Cell transplantation-based treatments for neurological disease are promising,
yet graft rejection remains a major barrier to successful regenerative therapies. Our group …

Currently, human glioma tumors are mostly modeled in immunodeficient recipients;
however, lack of interactions with adaptive immune system is a serious flaw, particularly in …

Background: Current radiotherapy regimens for glioblastoma (GBM) have limited efficacy
and fails to eradicate tumors. Regenerative medicine brings hope for repairing damaged …