Many mutations disappear from the population because they impair protein function and/or
stability. Thus, amino acid positions that are essential for proper function evolve more slowly …

▪ Abstract Comparative analysis of bacterial, archaeal, and eukaryotic genomes indicates
that a significant fraction of the genes in the prokaryotic genomes have been subject to …

The survival of viruses depends on their ability to resist host defenses and, of all animal virus
families, the poxviruses have the most antidefense genes. Orthopoxviruses (ORPV), a genus …

Probabilistic models are becoming increasingly important in analysing the huge amount of
data being produced by large-scale DNA-sequencing efforts such as the Human Genome …

Background All archaeal and many bacterial genomes contain Clustered Regularly
Interspaced Short Palindrome Repeats (CRISPR) and variable arrays of the CRISPR …

Chloroplasts arose from cyanobacteria, mitochondria arose from proteobacteria. Both
organelles have conserved their prokaryotic biochemistry, but their genomes are reduced …

Extremely halophilic archaea contain retinal-binding integral membrane proteins called
bacteriorhodopsins that function as light-driven proton pumps. So far, bacteriorhodopsins …

Key amino acid positions that are important for maintaining the 3D structure of a protein
and/or its function (s), eg catalytic activity, binding to ligand, DNA or other proteins, are often …

Background Sequencing the genomes of multiple, taxonomically diverse eukaryotes
enables in-depth comparative-genomic analysis which is expected to help in reconstructing …

Analysis of the 1,042,519–base pair Chlamydia trachomatis genome revealed unexpected
features related to the complex biology of chlamydiae. Although chlamydiae lack many …