Basal cell carcinomas: attack of the hedgehog
EH Epstein - Nature Reviews Cancer, 2008 - nature.com
Basal cell carcinomas (BCCs) were essentially a molecular'black box'until some 12 years
ago, when identification of a genetic flaw in a rare subset of patients who have a great …
ago, when identification of a genetic flaw in a rare subset of patients who have a great …
Polymorphisms in DNA repair genes and associations with cancer risk
EL Goode, CM Ulrich, JD Potter - Cancer epidemiology biomarkers & …, 2002 - AACR
Common polymorphisms in DNA repair genes may alter protein function and an individual's
capacity to repair damaged DNA; deficits in repair capacity may lead to genetic instability …
capacity to repair damaged DNA; deficits in repair capacity may lead to genetic instability …
[图书][B] DNA repair and mutagenesis
An essential resource for all scientists researching cellular responses to DNA damage.•
Introduces important new material reflective of the major changes and developments that …
Introduces important new material reflective of the major changes and developments that …
DNA repair/pro-apoptotic dual-role proteins in five major DNA repair pathways: fail-safe protection against carcinogenesis
C Bernstein, H Bernstein, CM Payne… - … Research/Reviews in …, 2002 - Elsevier
Two systems are essential in humans for genome integrity, DNA repair and apoptosis. Cells
that are defective in DNA repair tend to accumulate excess DNA damage. Cells defective in …
that are defective in DNA repair tend to accumulate excess DNA damage. Cells defective in …
XRCC1 , XRCC3 , XPD gene polymorphisms, smoking and 32 P-DNA adducts in a sample of healthy subjects
DNA repair genes have an important role in protecting individuals from cancer-causing
agents. Polymorphisms in several DNA repair genes have been identified and individuals …
agents. Polymorphisms in several DNA repair genes have been identified and individuals …
A multivariate analysis of genomic polymorphisms: prediction of clinical outcome to 5-FU/oxaliplatin combination chemotherapy in refractory colorectal cancer
In this marker evaluation study, we tested whether distinct patterns of functional genomic
polymorphisms in genes involved in drug metabolic pathways and DNA repair that predict …
polymorphisms in genes involved in drug metabolic pathways and DNA repair that predict …
Modulation of nucleotide excision repair capacity by XPD polymorphisms in lung cancer patients
Sequence variations have been identified in a number of DNA repair genes, including XPD,
but the effect of these polymorphisms on DNA repair capacity (DRC) is uncertain. We …
but the effect of these polymorphisms on DNA repair capacity (DRC) is uncertain. We …
XPD polymorphisms: effects on DNA repair proficiency
RM Lunn, KJ Helzlsouer, R Parshad… - …, 2000 - academic.oup.com
XPD codes for a DNA helicase involved in transcription and nucleotide excision repair. Rare
XPD mutations diminish nucleotide excision repair resulting in hypersensitivity to UV light …
XPD mutations diminish nucleotide excision repair resulting in hypersensitivity to UV light …
The xeroderma pigmentosum group D (XPD) gene: one gene, two functions, three diseases
AR Lehmann - Genes & development, 2001 - genesdev.cshlp.org
DNA, the genetic material in all living organisms, is continually exposed to agents that cause
damage to its structure, resulting in the loss of vital genetic information. To counteract the …
damage to its structure, resulting in the loss of vital genetic information. To counteract the …
The genetics of sun sensitivity in humans
JL Rees - The American Journal of Human Genetics, 2004 - cell.com
Humans vary> 100-fold in their sensitivity to the harmful effects of ultraviolet radiation. The
main determinants of sensitivity are melanin pigmentation and less-well-characterized …
main determinants of sensitivity are melanin pigmentation and less-well-characterized …