The sarcomere is the fundamental structural and functional unit of striated muscle and is
directly responsible for most of its mechanical properties. The sarcomere generates active or …

Cardiovascular diseases are the leading cause of death worldwide. Several strategies–
small molecules, gene therapy, surgeries, cardiac rehabilitation–have been developed to …

Background: During cardiomyocyte maturation, the centrosome, which functions as a
microtubule organizing center in cardiomyocytes, undergoes dramatic structural …

Fluorescence recovery after photobleaching (FRAP) has emerged as one of the most widely
utilized techniques to quantify binding and diffusion kinetics of biomolecules in biophysics …

Rationale Cardiac muscle cells are terminally differentiated after birth and must beat
continually throughout one's lifetime. This mechanical process is driven by the sliding of …

BACKGROUND: How the sarcomeric complex is continuously turned over in long-living
cardiomyocytes is unclear. According to the prevailing model of sarcomere maintenance …

Human induced pluripotent stem cell-derived cardiomyocytes (hiPSC-CMs) are currently
being explored for multiple in vitro applications and have been used in regulatory …

Cyclophosphamide (CPA) and doxorubicin (DOX) are key components of chemotherapy for
triple-negative breast cancer (TNBC), although suboptimal outcomes are commonly …

The Frank-Starling Law was proposed over 100 years ago, but it remains to be fully
explained at the molecular level. The Law states that when the volume of blood returning to …

In living cardiomyocytes, troponin's dynamic exchange occurs in the order of minutes, while
the giant titin shows a half-life of~ 1 h [1]. Rapid protein exchange arises from unbound …