Acute lymphoblastic leukaemia

L Pagliaro, SJ Chen, D Herranz, C Mecucci… - Nature Reviews …, 2024 - nature.com
Acute lymphoblastic leukaemia (ALL) is a haematological malignancy characterized by the
uncontrolled proliferation of immature lymphoid cells. Over past decades, significant …

Diagnosis, prognostic factors, and assessment of ALL in adults: 2024 ELN recommendations from a European expert panel

N Gökbuget, N Boissel, S Chiaretti, H Dombret… - Blood, 2024 - ashpublications.org
Working groups of the European LeukemiaNet have published several important consensus
guidelines. Acute lymphoblastic leukemia (ALL) has many different clinical and biological …

Acute myeloid leukemias with UBTF tandem duplications are sensitive to menin inhibitors

JM Barajas, M Rasouli, M Umeda, R Hiltenbrand… - Blood, 2024 - ashpublications.org
UBTF tandem duplications (UBTF-TDs) have recently emerged as a recurrent alteration in
pediatric and adult acute myeloid leukemia (AML). UBTF-TD leukemias are characterized by …

[HTML][HTML] The gene expression classifier ALLCatchR identifies B-cell precursor ALL subtypes and underlying developmental trajectories across age

T Beder, BT Hansen, AM Hartmann, J Zimmermann… - …, 2023 - journals.lww.com
Abstract Current classifications (World Health Organization-HAEM5/ICC) define up to 26
molecular B-cell precursor acute lymphoblastic leukemia (BCP-ALL) disease subtypes by …

Developmental trajectories and cooperating genomic events define molecular subtypes of BCR::ABL1-positive ALL

L Bastian, T Beder, MJ Barz, S Bendig, L Bartsch… - Blood, 2024 - ashpublications.org
Distinct diagnostic entities within BCR:: ABL1-positive acute lymphoblastic leukemia (ALL)
are currently defined by the International Consensus Classification of myeloid neoplasms …

Transcription factor UBF depletion in mouse cells results in downregulation of both downstream and upstream elements of the rRNA transcription network

A Theophanous, A Christodoulou, C Mattheou… - Journal of Biological …, 2023 - ASBMB
Transcription/processing of the ribosomal RNA (rRNA) precursor, as part of ribosome
biosynthesis, is intensively studied and characterized in eukaryotic cells. Here, we …

Insights into IGH clonal evolution in BCP-ALL: frequency, mechanisms, associations, and diagnostic implications

F Darzentas, M Szczepanowski, M Kotrová… - Frontiers in …, 2023 - frontiersin.org
Introduction The malignant transformation leading to a maturation arrest in B-cell precursor
acute lymphoblastic leukemia (BCP-ALL) occurs early in B-cell development, in a pro-B or …

Molecular subgroups of T-cell acute lymphoblastic leukemia in adults treated according to pediatric-based GMALL protocols

M Neumann, T Beder, L Bastian, S Hänzelmann… - Leukemia, 2024 - nature.com
In contrast to B-cell precursor acute lymphoblastic leukemia (ALL), molecular subgroups are
less well defined in T-lineage ALL. Comprehensive studies on molecular T-ALL subgroups …

Diagnosis of acute lymphoblastic leukaemia: an overview of the current genomic classification, diagnostic approaches, and future directions

W Walter, I Iacobucci, M Meggendorfer - Histopathology, 2025 - Wiley Online Library
B‐acute lymphoblastic leukaemia (B‐ALL) is a haematological disease resulting from
haematopoietic system dysfunction, leading to the unchecked growth of immature B …

Oncogenic lesions and molecular subtypes in adults with B‐cell acute lymphoblastic leukemia

T Yasuda, M Sanada, S Tsuzuki… - Cancer Science, 2023 - Wiley Online Library
B‐cell acute lymphoblastic leukemia (B‐ALL), a genetically heterogeneous disease, is
classified into different molecular subtypes that are defined by recurrent gene …