The impact of disease comorbidities in Alzheimer's disease

JA Santiago, JA Potashkin - Frontiers in aging neuroscience, 2021 - frontiersin.org
A wide range of comorbid diseases is associated with Alzheimer's disease (AD), the most
common neurodegenerative disease worldwide. Evidence from clinical and molecular …

Brain-gut axis dysfunction in the pathogenesis of traumatic brain injury

M Hanscom, DJ Loane… - The Journal of Clinical …, 2021 - Am Soc Clin Investig
Traumatic brain injury (TBI) is a chronic and progressive disease, and management requires
an understanding of both the primary neurological injury and the secondary sequelae that …

A fiber-deprived diet causes cognitive impairment and hippocampal microglia-mediated synaptic loss through the gut microbiota and metabolites

H Shi, X Ge, X Ma, M Zheng, X Cui, W Pan, P Zheng… - Microbiome, 2021 - Springer
Background Cognitive impairment, an increasing mental health issue, is a core feature of the
aging brain and neurodegenerative diseases. Industrialized nations especially, have …

Neuroinflammation represents a common theme amongst genetic and environmental risk factors for Alzheimer and Parkinson diseases

RJ Boyd, D Avramopoulos, LL Jantzie… - Journal of …, 2022 - Springer
Multifactorial diseases are characterized by inter-individual variation in etiology, age of
onset, and penetrance. These diseases tend to be relatively common and arise from the …

The role of Lactobacillus in inflammatory bowel disease: from actualities to prospects

C Li, K Peng, S Xiao, Y Long, Q Yu - Cell Death Discovery, 2023 - nature.com
Abstract Inflammatory Bowel Disease (IBD), a chronic nonspecific intestinal inflammatory
disease, is comprised of Ulcerative Colitis (UC) and Crohn's Disease (CD). IBD is closely …

What does disease progression look like in ulcerative colitis, and how might it be prevented?

NK Cleveland, J Torres, DT Rubin - Gastroenterology, 2022 - Elsevier
Ulcerative colitis (UC) has been characterized by inflammation limited to the mucosa.
Although sustained and durable remission has been associated with mucosal healing, the …

Gut-derived β-amyloid: Likely a centerpiece of the gut–brain axis contributing to Alzheimer's pathogenesis

J Jin, Z Xu, L Zhang, C Zhang, X Zhao, Y Mao… - Gut …, 2023 - Taylor & Francis
Peripheral β-amyloid (Aβ), including those contained in the gut, may contribute to the
formation of Aβ plaques in the brain, and gut microbiota appears to exert an impact on …

A large-scale genome-wide cross-trait analysis reveals shared genetic architecture between Alzheimer's disease and gastrointestinal tract disorders

EO Adewuyi, EK O'Brien, DR Nyholt, T Porter… - Communications …, 2022 - nature.com
Consistent with the concept of the gut-brain phenomenon, observational studies suggest a
relationship between Alzheimer's disease (AD) and gastrointestinal tract (GIT) disorders; …

Mechanistic link between vitamin B12 and Alzheimer's disease

AA Lauer, HS Grimm, B Apel, N Golobrodska, L Kruse… - Biomolecules, 2022 - mdpi.com
Alzheimer's disease (AD) is the most common form of dementia in the elderly population,
affecting over 55 million people worldwide. Histopathological hallmarks of this multifactorial …

A meta-analysis investigating the relationship between inflammation in autoimmune disease, elevated CRP, and the risk of dementia

J Cooper, Y Pastorello, M Slevin - Frontiers in Immunology, 2023 - frontiersin.org
Alzheimer's Disease (AD) represents the most common type of dementia and is becoming a
steadily increasing challenge for health systems globally. Inflammation is developing as the …