An update on drugs with therapeutic potential for SARS-CoV-2 (COVID-19) treatment
The COVID-19 pandemic is one of the greatest threats to human health in the 21st century
with more than 257 million cases and over 5.17 million deaths reported worldwide (as of …
with more than 257 million cases and over 5.17 million deaths reported worldwide (as of …
Thrombocytopathy and endotheliopathy: crucial contributors to COVID-19 thromboinflammation
The core pathology of coronavirus disease 2019 (COVID-19) is infection of airway cells by
severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) that results in excessive …
severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) that results in excessive …
Association between antecedent statin use and decreased mortality in hospitalized patients with COVID-19
A Gupta, MV Madhavan, TJ Poterucha… - Nature …, 2021 - nature.com
Abstract The coronavirus disease 2019 (COVID-19) can result in a hyperinflammatory state,
leading to acute respiratory distress syndrome (ARDS), myocardial injury, and thrombotic …
leading to acute respiratory distress syndrome (ARDS), myocardial injury, and thrombotic …
Association of lipid-lowering drugs with COVID-19 outcomes from a Mendelian randomization study
Background: Lipid metabolism plays an important role in viral infections. We aimed to
assess the causal effect of lipid-lowering drugs (HMGCR inhibitiors, PCSK9 inhibitiors, and …
assess the causal effect of lipid-lowering drugs (HMGCR inhibitiors, PCSK9 inhibitiors, and …
Understanding the molecular mechanisms of statin pleiotropic effects
CA German, JK Liao - Archives of Toxicology, 2023 - Springer
Statins represent the cornerstone of pharmacotherapy for the prevention of atherosclerotic
cardiovascular disease. These medications not only reduce low-density lipoprotein …
cardiovascular disease. These medications not only reduce low-density lipoprotein …
Routine use of statins and increased COVID-19 related mortality in inpatients with type 2 diabetes: results from the CORONADO study
Aim Patients with type 2 diabetes mellitus (T2DM) represent a high-risk population for both
cardiovascular diseases and severe coronavirus disease 2019 (COVID-19). Recent studies …
cardiovascular diseases and severe coronavirus disease 2019 (COVID-19). Recent studies …
Intermediate versus standard-dose prophylactic anticoagulation and statin therapy versus placebo in critically-ill patients with COVID-19: Rationale and design of the …
Background Microvascular and macrovascular thrombotic events are among the hallmarks
of coronavirus disease 2019 (COVID-19). Furthermore, the exuberant immune response is …
of coronavirus disease 2019 (COVID-19). Furthermore, the exuberant immune response is …
[HTML][HTML] Improved COVID-19 ICU admission and mortality outcomes following treatment with statins: a systematic review and meta-analysis
A Vahedian-Azimi, SM Mohammadi… - Archives of Medical …, 2021 - ncbi.nlm.nih.gov
Results The final selected studies (n= 24 studies; 32,715 patients) showed significant
reductions in ICU admission (OR= 0.78, 95% CI: 0.58–1.06; n= 10; I 2= 58.5%) and death …
reductions in ICU admission (OR= 0.78, 95% CI: 0.58–1.06; n= 10; I 2= 58.5%) and death …
[HTML][HTML] Active prescription of low-dose aspirin during or prior to hospitalization and mortality in COVID-19: A systematic review and meta-analysis of adjusted effect …
Background This study aimed to investigate whether the active prescription of low-dose
aspirin during or prior to hospitalization affects mortality in patients with coronavirus disease …
aspirin during or prior to hospitalization affects mortality in patients with coronavirus disease …
Estrogen hormone is an essential sex factor inhibiting inflammation and immune response in COVID-19
Although vaccines have been evaluated and approved for SARS-CoV-2 infection
prevention, there remains a lack of effective treatments to reduce the mortality of COVID-19 …
prevention, there remains a lack of effective treatments to reduce the mortality of COVID-19 …