Highlights•Cyclodextrins are complexing excipients in tablets mainly for potent
drugs.•Methods to enhance the complexation efficiency decrease the cyclodextrin …

Introduction: Mini-tablets represent a new trend in solid dosage form design, with the main
goal of overcoming some therapeutic obstacles such as impaired swallowing and …

Background: Cyclodextrins (CDs) are versatile excipients with an essential role in drug
delivery, as they can form non-covalently bonded inclusion complexes (host-guest …

Hundred years after the discovery of Chagas' disease, there is a lack of effective treatment to
control this neglected disease caused by the parasite Trypanosoma cruzi. The transmission …

The flavonoid naringenin (NAR) exhibits an outstanding anti-inflammatory potential;
however, stability problems and reduced solubility hinder its commercial insertion. This work …

This article describes the characterization of various encapsulated formulations of
benznidazole, the current first-line drug for the treatment of Chagas disease. Given the …

This study aimed to use thermal analysis and other analytical tools to guide the production of
thymol (TML) and essential oil of Lippia origanoides (EO) solid inclusion complexes from a …

Benznidazole (BZL) is the drug of choice for the treatment of Chagas' disease, a neglected
parasitic infection. It is poorly soluble in water, which may have a direct impact into its …

In order to improve the aqueous solubility and enhance the bioavailability of Hyperoside
(Hyp), three inclusion complexes (ICs) of Hyp with 2-hydroxypropyl-β-cyclodextrin (2H-β …

In the present study, we aimed to determine whether the shelf life of effervescent tablets may
be assessed during storage using total directional hemispherical reflectance (THR). We also …