Human skin and hair color are visible traits that can vary dramatically within and across
ethnic populations. The genetic makeup of these traits—including polymorphisms in the …

HERC proteins are ubiquitin E3 ligases of the HECT family. The HERC subfamily is
composed of six members classified by size into large (HERC1 and HERC2) and small …

Background Skin phenotype, host genotype and ultraviolet (UV) damage play a role in the
development of melanoma. Objectives To ascertain whether the level of UV damage at the …

Introduction Having many melanocytic naevi or 'moles' on the skin is the strongest predictor
of melanoma; thus, much can be learnt from investigating naevi in the general population …

Amelanotic/hypomelanotic melanoma is a clinicopathologic subtype with absent or minimal
melanin. This study assessed previously reported coding variants in albinism genes (TYR …

Melanoma, basal cell carcinoma (BCC) and squamous cell carcinoma (SCC) are the most
common skin cancers. The incidence rates of all three types of skin cancers have increased …

Background Amelanotic/hypomelanotic melanoma is associated with poorer outcomes due
to a more advanced disease stage at diagnosis. Objective To determine phenotypic risks …

Glaucoma is a common disorder in which the death of retinal ganglion cells (RGCs) results
in a progressive loss of sight, even blindness. This study was performed to reveal the key …

Eye color is highly variable in populations with European ancestry, ranging from low to high
quantities of melanin in the iris. Polymorphisms in the HERC2/OCA2 locus have the largest …

Iris tumors are relatively infrequent compared to similar ciliary tumors but comprise a broad
spectrum of benign and malignant pathologies. Due to the lack of metastatic potential …